BIOTRANSFORMATION AND PHARMACOKINETICS OF PYRETHROID INSECTICIDES

拟除虫菊酯类杀虫剂的生物转化和药代动力学

基本信息

  • 批准号:
    7171040
  • 负责人:
  • 金额:
    $ 10.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-07-01 至 2006-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The Center for Environmental Health Sciences (CEHS) within the CVM-MSU submits an application to develop a COBRE with the overall scientific theme of environmental health, and a specific emphasis on the toxicological effects of pesticides. Our COBRE would be a multi-disciplinary research effort with two overarching goals: 1) to develop individual junior faculty expertise and credibility so that each is recognized as a successful, fully enfranchised member of the community of environmental health scientists with independent, competitive funding support from peer-reviewed mechanisms (primarily R01 grants); and 2) to develop a team of scientists who can compete for programmatic research support, such as a program project grant, for investigation of environmental health problems elicited by agricultural chemicals. Organizationally, an Administrative Core would coordinate overall activities of the COBRE, and be responsible for mentoring the junior scientists in their career development to increase their competitiveness, and for data management activities (data entry and statistical guidance). Four biomedical mechanistic research projects will be based on hypothesis-driven studies of the potential effects of pesticides on the mammalian nervous or endocrine systems at various stages of development (from early development through aging). The mechanisms of toxicity of pesticides will be investigated in animal models (both traditional laboratory rodents as well as new animal models). A Research Resources Core would provide infrastructure to these biomedical projects through animal resources; (Animal Sub-Core) and shared instrumentation (Imaging Sub-Core and Analytical Chemistry Sub-Core). In addition, an epidemiology and exposure assessment project would bring real world perspectives to the biochemical and physiological mechanisms under study. Renovation of laboratory space would occur. The Principal Investigators (PI) of the science projects are junior faculty who demonstrate distinct but complementary areas of expertise, all of whom can contribute individually and programmatically to answering critical questions in the assessment of the impact of pesticides on selected areas of human health. All are committed to developing new or expanded expertise in scientific questions or methodologies useful in the area of environmental health, and that fit the priority research areas of the National Institute of Environmental Health Sciences (NIEHS), for whose support we hope to ultimately compete.
描述(由申请人提供):CVM-MSU 内的环境健康科学中心 (CEHS) 提交了一份开发 COBRE 的申请,该 COBRE 的总体科学主题是环境健康,并特别强调农药的毒理学效应。我们的 COBRE 将是一项多学科研究工作,有两个总体目标:1)发展个人初级教师的专业知识和可信度,使每个人都被认为是环境健康科学家社区中成功的、完全享有权利的成员,并获得来自同行评审机制(主要是 R01 拨款)的独立、有竞争力的资助支持; 2) 培养一支能够竞争规划研究支持(例如规划项目拨款)的科学家团队,以调查农业化学品引起的环境健康问题。在组织上,行政核心将协调 COBRE 的整体活动,并负责指导初级科学家的职业发展以提高其竞争力,并负责数据管理活动(数据录入和统计指导)。四个生物医学机制研究项目将基于假设驱动的研究,研究农药对不同发育阶段(从早期发育到衰老)的哺乳动物神经或内分泌系统的潜在影响。将在动物模型(传统的实验室啮齿动物和新的动物模型)中研究农药的毒性机制。研究资源核心将通过动物资源为这些生物医学项目提供基础设施; (动物子核心)和共享仪器(成像子核心和分​​析化学子核心)。此外,流行病学和暴露评估项目将为正在研究的生化和生理机制带来现实世界的视角。实验室空间将进行翻新。科学项目的首席研究员 (PI) 是初级教师,他们表现出独特但互补的专业知识领域,所有这些人都可以单独和有计划地为回答评估农药对人类健康选定领域的影响的关键问题做出贡献。所有这些都致力于在环境健康领域有用的科学问题或方法学方面开发新的或扩展的专业知识,并且适合国家环境健康科学研究所 (NIEHS) 的优先研究领域,我们希望最终能够获得其支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MATTHEW K ROSS其他文献

MATTHEW K ROSS的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MATTHEW K ROSS', 18)}}的其他基金

Crosstalk between CES1 and PPAR gamma and LXR alpha in macrophages
巨噬细胞中 CES1 与 PPAR γ 和 LXR α 之间的串扰
  • 批准号:
    10359914
  • 财政年份:
    2022
  • 资助金额:
    $ 10.79万
  • 项目类别:
Effect of Organophoshate Exposure on Cholesteryl Ester Hydrolase
有机磷酸盐暴露对胆固醇酯水解酶的影响
  • 批准号:
    7811262
  • 财政年份:
    2009
  • 资助金额:
    $ 10.79万
  • 项目类别:
Effect of Organophoshate Exposure on Cholesteryl Ester Hydrolase
有机磷酸盐暴露对胆固醇酯水解酶的影响
  • 批准号:
    7908563
  • 财政年份:
    2009
  • 资助金额:
    $ 10.79万
  • 项目类别:
Effect of Organophoshate Exposure on Cholesteryl Ester Hydrolase
有机磷酸盐暴露对胆固醇酯水解酶的影响
  • 批准号:
    7304498
  • 财政年份:
    2007
  • 资助金额:
    $ 10.79万
  • 项目类别:
Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
巨噬细胞中的脂质甘油酯稳态和环境扰动
  • 批准号:
    8232778
  • 财政年份:
    2007
  • 资助金额:
    $ 10.79万
  • 项目类别:
KINETIC ANALYSES OF SITE-SPECIFIC MUTANTS OF CARBOXYLESTERASES
羧基酯酶位点特异性突变体的动力学分析
  • 批准号:
    7381820
  • 财政年份:
    2006
  • 资助金额:
    $ 10.79万
  • 项目类别:
BIOTRANSFORMATION AND PHARMACOKINETICS OF PYRETHROID INSECTICIDES
拟除虫菊酯类杀虫剂的生物转化和药代动力学
  • 批准号:
    7381816
  • 财政年份:
    2006
  • 资助金额:
    $ 10.79万
  • 项目类别:
BIOTRANSFORMATION OF PYRETHROID INSECTICIDES
拟除虫菊酯杀虫剂的生物转化
  • 批准号:
    6981726
  • 财政年份:
    2004
  • 资助金额:
    $ 10.79万
  • 项目类别:
Trihalomethane Pharmacokinetics and Pharmacodynamics
三卤甲烷药代动力学和药效学
  • 批准号:
    6525336
  • 财政年份:
    2002
  • 资助金额:
    $ 10.79万
  • 项目类别:
Trihalomethane Pharmacokinetics and Pharmacodynamics
三卤甲烷药代动力学和药效学
  • 批准号:
    6747546
  • 财政年份:
    2002
  • 资助金额:
    $ 10.79万
  • 项目类别:

相似海外基金

Environmental Agents as Modulators of Disease Processes
环境因素作为疾病过程的调节剂
  • 批准号:
    10852393
  • 财政年份:
    2023
  • 资助金额:
    $ 10.79万
  • 项目类别:
An in vivo multiplex model to study gene-environment interaction in Parkinson's Disease
研究帕金森病基因与环境相互作用的体内多重模型
  • 批准号:
    10843389
  • 财政年份:
    2023
  • 资助金额:
    $ 10.79万
  • 项目类别:
Early life metal exposure, the gut microbiome, and neurodevelopment in childhood
生命早期的金属暴露、肠道微生物组和儿童期的神经发育
  • 批准号:
    10883857
  • 财政年份:
    2023
  • 资助金额:
    $ 10.79万
  • 项目类别:
Role of Prokineticin 2 in Metal Neurotoxicity
Prokineticin 2 在金属神经毒性中的作用
  • 批准号:
    10587599
  • 财政年份:
    2023
  • 资助金额:
    $ 10.79万
  • 项目类别:
New statistical and computational tools for optimization of planarian behavioral chemical screens
用于优化涡虫行为化学筛选的新统计和计算工具
  • 批准号:
    10658688
  • 财政年份:
    2023
  • 资助金额:
    $ 10.79万
  • 项目类别:
Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type Effects
围产期铅暴露导致阿尔茨海默病和相关痴呆的风险:大脑区域和细胞类型的影响
  • 批准号:
    10369814
  • 财政年份:
    2022
  • 资助金额:
    $ 10.79万
  • 项目类别:
CSRD Research Career Scientist Award Application
CSRD研究职业科学家奖申请
  • 批准号:
    10657613
  • 财政年份:
    2022
  • 资助金额:
    $ 10.79万
  • 项目类别:
Core B: Neuroimaging Core
核心 B:神经影像核心
  • 批准号:
    10684077
  • 财政年份:
    2022
  • 资助金额:
    $ 10.79万
  • 项目类别:
Research Education Core
研究教育核心
  • 批准号:
    10684071
  • 财政年份:
    2022
  • 资助金额:
    $ 10.79万
  • 项目类别:
International Neurotoxicology Association (INA) Conference
国际神经毒理学协会(INA)会议
  • 批准号:
    10601313
  • 财政年份:
    2022
  • 资助金额:
    $ 10.79万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了