Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response

基因表达生物标志物预测严重哮喘炎症表型、激活机制和治疗反应

• 批准号: nhmrc : 1045371
• 负责人: Dr Katherine Baines
• 金额: $ 31.05万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-expression-biomarkers-treatment-response/111741
• 关键词: Gene; Expression; Biomarkers; Predict; Severe

Asthma is now recognised to be made up of several disease variants or phenotypes, which are likely to have different underlying causes and mechanisms. We lack understanding of how to identify phenotypes of asthma and how they work, and this is delaying research that will lead to improvements in treatments and patient care. This is particularly important in people with severe disease. This grant will establish a gene test to identify asthma phenotype, and further understand mechanisms and treatment responses.

哮喘现在被认为是由几种疾病变异或表型组成的，这些变异或表型可能有不同的潜在原因和机制。我们对如何识别哮喘的表型以及它们如何起作用缺乏了解，这耽误了将改善治疗和患者护理的研究。这对患有严重疾病的人尤其重要。这笔拨款将建立一个基因测试，以确定哮喘表型，并进一步了解机制和治疗反应。