Targeting neutrophil extracellular traps to reduce inflammation in severe asthma

靶向中性粒细胞胞外陷阱以减少严重哮喘的炎症

• 批准号: nhmrc : 1104645
• 负责人: Dr Katherine Baines
• 金额: $ 40.51万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-neutrophil-extracellular-severe-asthma/662772
• 关键词: Targeting; neutrophil; extracellular; traps; reduce

People with severe asthma, a chronic disease of the lungs, often have many inflammatory cells in the airways called neutrophils. Neutrophils release a meshwork of fibers in a web like trap called NETs, which are made of the cells DNA and other proteins that fight infection. These NETs can promote inflammation in the persons airways. Current asthma treatments have no effect on NETs. This project will measure NETs in the airways and test a new treatment to reduce NETs, and relieve asthma symptoms.

患有严重哮喘的人，一种慢性肺部疾病，通常在气道中有许多称为中性粒细胞的炎症细胞。中性粒细胞在称为NET的网状陷阱中释放出纤维网，这些陷阱由细胞DNA和其他抗感染的蛋白质组成。这些NET可以促进人的气道炎症。目前的哮喘治疗对NET没有影响。该项目将测量气道中的NET，并测试一种新的治疗方法，以减少NET，缓解哮喘症状。