Targeting neutrophil extracellular traps to reduce inflammation in severe asthma

患有严重哮喘的人，一种慢性肺部疾病，通常在气道中有许多称为中性粒细胞的炎症细胞。中性粒细胞释放出一个网状的纤维网，称为NET，它是由细胞DNA和其他抗感染的蛋白质组成的。这些NET可以促进人的气道炎症。目前的哮喘治疗对NET没有影响。该项目将测量气道中的NET，并测试一种新的治疗方法，以减少NET，缓解哮喘症状。

People with severe asthma, a chronic disease of the lungs, often have many inflammatory cells in the airways called neutrophils. Neutrophils release a meshwork of fibers in a web like trap called NETs, which are made of the cells DNA and other proteins that fight infection. These NETs can promote inflammation in the persons airways. Current asthma treatments have no effect on NETs. This project will measure NETs in the airways and test a new treatment to reduce NETs, and relieve asthma symptoms.