Understanding how azithromycin prevents exacerbations in severe asthma

在一些患有严重哮喘的人中，传统的吸入器治疗无法控制疾病，因此需要新的治疗方案。我们最近完成了一项大型临床试验，该试验表明，在这种情况下，极低剂量的普通抗生素有助于预防哮喘发作。然而，关于这种抗生素是如何起作用的，人们知之甚少。这项研究将帮助我们了解抗生素是如何起作用的，以及哪些人反应最好。

In some people with severe asthma, conventional inhaler treatments are not able to control the disease so there is a need for new treatment options. We have recently completed a large clinical trial which showed that very low doses of a common antibiotic help prevent asthma attacks in this situation. However, not much is known about how the antibiotic is working. This study will help us understand how the antibiotic is working and which people respond best.