Understanding how azithromycin prevents exacerbations in severe asthma

了解阿奇霉素如何预防严重哮喘病情加重

• 批准号: nhmrc : GNT1144941
• 负责人: Dr Katherine Baines
• 金额: $ 69.73万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-azithromycin-prevents-severe-asthma/1348648
• 关键词: Understanding; how; azithromycin; prevents; exacerbations

In some people with severe asthma, conventional inhaler treatments are not able to control the disease so there is a need for new treatment options. We have recently completed a large clinical trial which showed that very low doses of a common antibiotic help prevent asthma attacks in this situation. However, not much is known about how the antibiotic is working. This study will help us understand how the antibiotic is working and which people respond best.

在一些严重哮喘患者中，传统的吸入器治疗无法控制疾病，因此需要新的治疗方案。我们最近完成了一项大型临床试验，该试验表明，在这种情况下，非常低剂量的普通抗生素有助于预防哮喘发作。然而，人们对抗生素的作用机制知之甚少。这项研究将帮助我们了解抗生素是如何起作用的，以及哪些人的反应最好。