BioCurrents Research Center

生物电流研究中心

• 批准号: 6850350
• 负责人: PETER JS SMITH
• 金额: $ 157.86万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6850350
• 关键词: bioengineering /biomedical engineering; biomedical equipment resource; biomedical resource; electrical potential; electrodes; ion transport

DESCRIPTION (Adapted from the Applicant's abstract): The overall objective of the BRC initiative is to provide technologies suitable to resolve the functional complexity of the living cell with emphasis on diffusive boundary layers surrounding cells and tissues and correlating the data to the activity of the cell in sub-cellular domains. That initiative requires a continuous development of electrochemical micro-sensors and their applications for detection of important biological molecules through collaborative research projects. This proposal is a continuation of previous research efforts in scope of sensor speed, selectivity and "poisoning" by compounds used in experimental conditions. Major improvement of the sensor performance is claimed in sensor construction. The applicants plan to pursue the sensor construction with a commercial initiative -BioCurrents Research Inc. (BRI) - assuming successful funding of Phase II STTR award or to continue independently. Furthermore, it is planned to continue the development of the BioKelvin probe now renamed to the Bioelectric Field Imager (BFI) device with a goal of clinical application to skin disease within a collaborative work with General Medicine. There are 4 specific aims within the 4A: 1; (1) to continue investigation of ISE in "self-referencing mode" (Seris), (2) to continue development of amperometric -redox based electrodes in self-referencing mode (Sera) (a) by continuing further development of existing electrodes and (b) by initiating development of application of new sensors design -sol-gels and Os gels, (3) to continue development and innovation in hardware and software support, and (4) to improve production of the Whalen design amperometric O2 sensor.

描述(改编自申请人的摘要)：BRC倡议的总体目标是提供适合于解决活细胞功能复杂性的技术，重点是细胞和组织周围的扩散边界层，并将数据与亚细胞域中细胞的活动相关联。这一倡议要求通过合作研究项目不断开发电化学微型传感器及其在检测重要生物分子方面的应用。这项建议是对先前在传感器速度、选择性和在实验条件下使用的化合物的“中毒”范围内研究工作的继续。在传感器结构方面，传感器性能有了很大的提高。 申请者计划通过一个商业倡议--BioCurrents Research Inc.(BRI)--继续传感器建设，前提是成功资助第二阶段STTR奖励，或者继续独立进行。此外，计划继续开发BioKelvin探头，现已更名为生物电场成像仪(BFI)设备，目标是与普通医学合作将其临床应用于皮肤病。 4A有4个具体目标：1、(1)继续在“自参考模式”(SERIS)中研究ISE；(2)在自参考模式(SERA)中继续开发基于安培-氧化还原的电极；(A)通过继续进一步开发现有电极和(B)开始开发新传感器设计的应用--溶胶凝胶和Os凝胶；(3)在硬件和软件支持方面继续开发和创新；以及(4)改进惠伦设计的安培O2传感器的生产。