CALCIUM DYNAMICS AND EGG ACTIVATION

钙动力学和卵子激活

• 批准号: 7182556
• 负责人: JOHN A WAGNER
• 金额: $ 2.09万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7182556
• 关键词: bioimaging /biomedical imaging; biomedical resource; cell biology; computer simulation; image processing; method development; model design /development; parallel processing

DESCRIPTION (as provided by applicant): The National Resource for Cell Analysis and Modeling is housed within, and is the principal venture of, the Center for Biomedical Imaging Technology (CBIT) at the University of Connecticut Health Center. The Resource contains state of the art facilities for studying living cells and has developed a new technology, the Virtual Cell, for analyzing and synthesizing this knowledge. The Virtual Cell is a general framework for modeling cell biological processes. It approaches the problem by associating biochemical and electrophysiological data describing individual reactions with experimental microscopic image data describing their cellular locations. Individual processes are integrated within a physical and computational infrastructure that will accommodate any molecular mechanism. That this computational technology is being developed within a research center fully equipped for microscopic studies of living cells assures that experiment and theory drive each other synergistically. The research plan for the technology development is divided into two projects centered on theory and three that are primarily experimental. Computational Infrastructure addresses the issues of layering the cell biological models on a transparent physical and mathematical foundation, implementing the numerical methods in a distributed computing environment; and refining the remotely accessible user interface and associated database of images and reaction mechanisms. Mathematical and Physical Analysis of Cell Biological Processes has 3 goals: formulation of generalized mathematical descriptions of the elementary physical processes underlying the myriad of cell biological mechanisms; development and validation of efficient numerical methods; and development of rigorous methods for building and refining models from experimental data. Calcium Dynamics aims to elucidate intracellular calcium signaling in cells via a systematic marriage of experiment and modeling approaches;

描述(由申请人提供)：国家细胞分析和建模资源位于康涅狄格大学健康中心的生物医学成像技术中心(CBIT)内，是该中心的主要合资企业。该资源包含了研究活细胞的最先进的设施，并开发了一种新技术，虚拟细胞，用于分析和合成这一知识。虚拟细胞是模拟细胞生物学过程的通用框架。它通过将描述个体反应的生化和电生理数据与描述细胞位置的实验显微图像数据相关联来解决这个问题。单独的过程被集成在一个物理和计算基础设施中，可以容纳任何分子机制。这项计算技术是在一个完全配备了活细胞微观研究的研究中心内开发的，这确保了实验和理论相互协同推动。该技术开发的研究计划分为两个以理论为中心的项目和三个以实验为主的项目。计算基础设施解决了在透明的物理和数学基础上分层细胞生物学模型、在分布式计算环境中实施数值方法以及改进远程可访问的用户界面和相关的图像和反应机制数据库的问题。细胞生物学过程的数学和物理分析有三个目标：对无数细胞生物学机制下的基本物理过程的广义数学描述；开发和验证有效的数值方法；以及开发从实验数据建立和精炼模型的严格方法。钙动力学旨在通过实验和建模方法的系统结合来阐明细胞内的钙信号；