CORE--DATA MANAGEMENT AND STATISTICS

数据管理和统计核心是满足所有统计和数据管理需求的核心资源。其他核心和研究项目生成的数据将被传输到数据库组件，以便输入和存储在集成SIR/DBMS数据管理系统中，该系统旨在满足中心在计划和临时分析数据的清理、组织和检索方面的所有需求。这些活动将由一名数据管理员和一名数据输入员在核心主任的直接监督下在专门为数据管理操作配置的奔腾PC联网系统上进行。DMS核心将继续每周与研究项目和其他核心的协调员和研究者举行会议，讨论所有数据相关问题，包括患者招募、数据完整性、检索和统计分析。统计部分将负责协调调查人员在所有核心和项目中进行的所有分析的规划和执行。拟议的研究项目具有某些共同的特征，这些特征适用于类似的分析方法，包括切碎的前瞻性队列，纵向数据的收集，认知结果和关于随时间变化的假设，将使用生存分析进行分析。DMS核心将把1999年队列中招募的估计2 000名受试者纳入现有的WHICAP数据库系统，该系统现在包含最初的1992年队列。将执行该过程，以便原始队列和新队列的数据不仅可以轻松合并用于两组的计划分析，而且可以轻松区分和分离用于队列特定分析。与两组合作，但也容易区分和分离，用于队列特异性分析。DMS核心将与其他核心合作，编写程序化报告，以便利对1999年同期组群成员以及原同期组群幸存成员进行年度跟踪，并将编写报告，向项目协调员提供与每个受试者联系所需的所有信息。

The Data Management and Statistics (DMS) Core constitutes the central resource for all statistical and data management needs. Data generated by each of the other cores and research projects will be transferred to the Database Component for entry and storage in an integrated SIR/DBMS data management system designed to meet all the needs of the Center with respect to cleaning, organization and retrieval of data for planned and ad hoc analyses. These activities will be carried out by a data manager and a data entry clerk working directly under the supervision of the Core director on a networked system of Pentium PCs specifically configured for data management operations. The DMS Core will continue to conduct weekly meetings with coordinators and investigators from the research projects and other cores to discuss all data-related issues, including patient accrual, data completeness, retrieval and statistical analysis. The Statistics Component will be responsible for coordinating the planning and implementation of all analyses conducted by investigators in all cores and projects. The proposed research projects have certain features in common that lend themselves to similar analytic methods, including a shred prospective cohort, collection of longitudinal data, cognitive outcomes and hypothesis regarding change over time that will be analyzed using survival analysis. The DMS Core will incorporate the estimated 2,000 subjects to be recruited in the 1999 cohort into the existing WHICAP data basing system, which now contains the original 1992 cohort. This process will be carried out so that data from the original cohort and the new cohort can not only be easily combined for planned analyzes of both groups, but also readily distinguished and separated for cohort-specific analyses. In collaboration with both groups, but also readily distinguished and separated for cohort- specific analyses. In collaboration with other cores, the DMS Core will develop programmed reports to facilitate annual follow up of members of the 1999 cohort as well as surviving members of the original cohort and will develop reports to provide the project coordinator with all information necessary to contact each subject.