BIOSTATISTICAL AND DATA MANAGEMENT CORE

所有SPOTRIAS项目的数据在过去五年中一直得到管理，并将继续得到管理。 在BDM核心负责人霍华德Andrews博士的监督下，在设计和维护的单一集成哥伦比亚SPOTRIAS数据库中对更新期进行管理。安德鲁斯博士也是哥伦比亚梅尔曼公共卫生学院（MSPH）数据协调中心（DCC）的主任，该中心隶属于MSPH生物统计学系，并为哥伦比亚附属机构纽约州精神病研究所（NYSPl）提供服务。SPOTRIAS数据库位于NYSPl的IT人员维护的物理和电子安全服务器集群上。核心B数据库经理Greg Neils先生与Andrews博士和SPOTRIAS研究者和协调员协商，并在核心B程序员大卫梅丽先生的协助下，设计并实施了哥伦比亚SPOTRIAS集成SPOTRIAS数据库以及过去五年中纳入该数据库的关键功能。MSPH生物统计部门的主要任命高级统计学家Myunghee Paik博士和Ken Cheung博士传统上负责监督神经科临床试验的统计咨询和数据分析，在过去五年中领导了SPOTRIAS统计部分，并将在拟议的更新期内继续这样做。埃里克·扎拉恩博士， 神经学研究所的副研究科学家，是神经成像数据分析方面的专家，包括统计参数映射和动态因果建模。Paik博士将全面领导统计部分，为DESERVE（项目3，鼓励减少血管事件的卒中出院教育策略）提供统计设计咨询，并将监督数据分析师Margaret Doyle的工作，他负责项目1和2的分析。Cheung博士是NeuSTART（项目1，他汀类药物治疗急性恢复试验的神经保护）的高级统计学家，Zarahn博士是项目2，急性卒中后恢复：多模式调查的高级统计学家。

Data for all SPOTRIAS projects has been managed for the previous five years, and will continue to be managed in the renewal period within a single integrated Columbia SPOTRIAS database designed and maintained under the oversight of BDM core leader Dr. Howard Andrews. Dr. Andrews is also director of the Data Coordinating Center (DCC) at the Columbia Mailman School of Public Health (MSPH), which is affiliated with the MSPH Biostatistics Department and which also serves the New York State Psychiatric Institute (NYSPl), a Columbia affiliate. The SPOTRIAS database resides on a physically and electronically secure server cluster maintained by the IT staff of NYSPl. Mr. Greg Neils, the Core B database manager, in consultation with Dr. Andrews and SPOTRIAS investigators and coordinators, and with the assistance of the Core B programmer, Mr. David Merie, designed and implemented the Columbia SPOTRIAS integrated SPOTRIAS database and the key functionalities that have been incorporated into the database over the past five years. Senior statisticians with primary appointments in the MSPH Biostatistics Department, Dr. Myunghee Paik and Dr. Ken Cheung, have traditionally overseen statistical consultation and data analysis for Clinical Trials in the Department of Neurology, have provided leadership for the SPOTRIAS statistical component for the past five years, and will continue to do so in the proposed renewal period. Dr. Eric Zarahn, Associate Research Scientist at the Neurological Institute, is an expert in neuroimaging data analysis, including Statistical Parametric Mapping and Dynamic Causal Modeling. Dr. Paik will provide overall leadership of the Statistics Component, statistical design consultation to DESERVE (Project 3, Discharge Educational Strategies in Stroke to Encourage Reduction of Vascular Events), and will oversee the work of the data analyst, Margaret Doyle, who conducts the analyses for Projects 1 and 2. Dr. Cheung is the senior statistician for NeuSTART (Project 1, Neuroprotection with Statin Therapy for Acute Recovery Trial), and Dr. Zarahn is senior statistician for Project 2, Recovery after Acute Stroke: a Multi-modal Investigation.