Investigating functional conservation of Specialized ribosomes in eukaryotes

研究真核生物中特殊核糖体的功能保护

• 批准号: 2881105
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2881105
• 关键词: Investigating; functional; conservation; Specialized; ribosomes

Ribosomes are the ancient cellular machines that perform protein synthesis. Although long considered uniform in both composition and function, recent findings have shown ribosomes to be far more heterogeneous than originally thought. Heterogeneity can give rise to specialized ribosomes and provide a novel means by which gene expression can be regulated, through the selective expression of a subset of mRNAs. You will investigate ribosome specialization in yeast and human pluripotent stem cells using a combination of state-of-the art mass spec, transcriptomic and functional approaches. The work underlying this project will help to understand an exciting and fundamental mechanism regulating gene expression.

核糖体是执行蛋白质合成的古老细胞机器。虽然长期以来人们认为核糖体在组成和功能上都是一致的，但最近的发现表明，核糖体的异质性比最初认为的要多得多。异质性可以产生专门的核糖体，并提供一种新的方法，通过选择性地表达一组mRNAs来调节基因的表达。你将使用最先进的质谱学、转录学和功能学相结合的方法研究酵母和人类多能干细胞中的核糖体特化。这个项目背后的工作将有助于理解一种令人兴奋的、基本的调控基因表达的机制。