Mechanisms of Arterial Dysfunction in Type 2 Diabetes Mellitus

2 型糖尿病动脉功能障碍的机制

• 批准号: 7524091
• 负责人: MARK A CREAGER
• 金额: $ 33.23万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7524091
• 关键词: 1-Phosphatidylinositol 3-Kinase; Accounting; Adipocytes; Adipose tissue; Agreement; Amputation; Antiatherogenic; Atherosclerosis; Attenuated; Biological Assay; Biological Preservation; Biology; Biopsy Specimen; Blood Vessels; C-reactive protein; CD40 Ligand; Cardiovascular system; Cause of Death; Cerebrovascular Disorders; Clinical; Coronary Arteriosclerosis; Cross-Over Studies; Crossover Design; Cutaneous; Deoxyglucose; Development; Diabetes Mellitus; Diffuse; Dose; Endothelium; Euglycemic Clamping; Event; Experimental Models; Fat emulsion; Forearm; Functional disorder; Glucose; Glucose Clamp; Goals; Heat-Shock Proteins 90; Heparin; Homeostasis; Hyperglycemia; Inflammation; Inflammation Mediators; Inflammatory; Infusion procedures; Insulin; Insulin Receptor; Insulin Resistance; Interleukin-6; Investigation; Lead; Measurement; Measures; Mediating; Mediator of activation protein; Molecular; Muscle; Myocardial Infarction; NF-kappa B; Nitric Oxide; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Pathway interactions; Patients; Peripheral; Peripheral arterial disease; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Placebo Control; Placebos; Plasma; Plethysmography; Positron-Emission Tomography; Prevalence; Principal Investigator; Production; Program Research Project Grants; Protein Kinase C; Proto-Oncogene Proteins c-akt; Randomized; Regulation; Research Personnel; Resistance; Resolution; Rho-associated kinase; Risk; Serine; Severities; Signal Pathway; Signal Transduction; Skeletal Muscle; Skeletal system; Skin; Stroke; Testing; Therapeutic; Tissues; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tyrosine Phosphorylation; Ultrasonography; Vascular Diseases; Vasodilation; Venous; abstracting; acipimox; brachial artery; cytokine; diabetic; disability; fasudil; fatty acid metabolism; glucose uptake; human NOS3 protein; human TNF protein; human subject; improved; in vivo; insight; insulin receptor substrate 1 protein; insulin secretion; insulin sensitivity; insulin signaling; kinase inhibitor; muscle metabolism; programs; research study; salicylsalicylic acid; therapeutic target; treatment duration