Generating sophisticated multi-component scaffolding to advance neural stem/progenitor cell transplantation technology

生成复杂的多组件支架以推进神经干/祖细胞移植技术

• 批准号: nhmrc : 1050684
• 负责人: A/Pr David Nisbet
• 金额: $ 27.69万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generating-sophisticated-multi-transplantation-technology/112169
• 关键词: Generating; sophisticated; multi; component; scaffolding

If stem cell transplantation is to be useful to repair brain injury, advancement must be made to improve the delivery, survival and differentiation of transplanted cells so that they can sufficiently integrate into the host brain. Here, self-assembling peptides will be developed to provide physical and biochemical support for stem cells and neurones in cell culture (which may be useful for drug discovery) and following transplantation into the injured brain.

如果干细胞移植对修复脑损伤有用，就必须改进移植细胞的输送、存活和分化，以便它们能够充分整合到宿主大脑中。在这里，自组装肽将被开发为细胞培养中的干细胞和神经元提供物理和生化支持（这可能对药物发现有用），并在移植到受伤的大脑中。