Understanding the pathogenesis of mitochondrial disease using iPS cells

使用 iPS 细胞了解线粒体疾病的发病机制

• 批准号: nhmrc : 1022222
• 负责人: A/Pr David Nisbet
• 金额: $ 42.7万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-pathogenesis-mitochondrial-ips-cells/110175
• 关键词: Understanding; pathogenesis; mitochondrial; disease; using

Induced pluripotent stem (iPS) cells are stem cells derived from adult skin cells that can be converted into cell types such as neurons. iPS cells offer great promise in understanding and treating inherited disorders. However, there are concerns that the “epigenetic memory” of iPS cells has not been completely erased, which may limit the utility of iPS cells. We will evaluate and validate the use of iPS technology in mouse and human models of inherited disorders affecting energy generation.

诱导多能干细胞（iPS）是来源于成体皮肤细胞的干细胞，可以转化为神经元等细胞类型。iPS细胞为理解和治疗遗传性疾病提供了巨大的希望。然而，有人担心iPS细胞的“表观遗传记忆”尚未完全消除，这可能会限制iPS细胞的实用性。我们将评估和验证iPS技术在影响能量产生的遗传性疾病的小鼠和人类模型中的应用。