Treating Parkinson's Disease Dementia with Nanoscaffolds

用纳米支架治疗帕金森病痴呆

• 批准号: nhmrc : GNT1135657
• 负责人: A/Pr David Nisbet
• 金额: $ 66.51万
• 依托单位国家: 澳大利亚
• 项目类别: Boosting Dementia Research Initiative
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/treating-parkinsons-disease-dementia-nanoscaffolds/1347986
• 关键词: Treating; Parkinson; Disease; Dementia; Nanoscaffolds

Several diseases, including Parkinson’s disease (PD), result in dementia. Currently, pharmacological therapy is the only treatment for PD dementia, which only offers symptomatic relief with diminished efficacy. Therefore, there is a need to develop new strategies that prevent or slow the onset of dementia. This study will utilize nanoscaffolds that facilitate the controlled delivery of therapeutic proteins to prevent or slow the death of neurons associated with dementia in PD patients.

包括帕金森病（PD）在内的几种疾病会导致痴呆。目前，药物治疗是PD痴呆的唯一治疗方法，仅提供症状缓解，疗效降低。因此，有必要开发新的策略来预防或减缓痴呆症的发作。这项研究将利用纳米支架，促进治疗性蛋白质的受控递送，以预防或减缓PD患者中与痴呆相关的神经元死亡。