Regulating astrocytosis for appropriate defence and repair of the brain after injury

调节星形细胞增多，以实现损伤后大脑的适当防御和修复

• 批准号: nhmrc : 1020332
• 负责人: A/Pr David Nisbet
• 金额: $ 37.52万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulating-astrocytosis-appropriate-brain-injury/110022
• 关键词: Regulating; astrocytosis; appropriate; defence; repair

An inflammatory process, designed to clean up cell debris and maintain tissue integrity following brain insult, also results in an astrocytic scar that biochemically impedes nerve repair. After 8 weeks astrocytes switch to become supportive, however once a scar is formed repair is permanently inhibited. Here, we will test the ability of biomaterials to optimise the timing of the necessary inflammatory phase, to encourage repair by converting astrocytes to their tropic phase more rapidly.

在脑损伤后，一个旨在清除细胞碎片和保持组织完整性的炎症过程也会导致星形细胞疤痕，从生化上阻碍神经修复。8周后，星形胶质细胞转变为支持性细胞，然而一旦形成疤痕，修复就永久受到抑制。在这里，我们将测试生物材料的能力，以优化必要的炎症阶段的时间，通过更快地将星形胶质细胞转化为趋化期来鼓励修复。