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Generating Tumour-Specific Dendritic Cells for Cancer Therapy

生成肿瘤特异性树突状细胞用于癌症治疗

基本信息

批准号：
nhmrc : 454393
负责人：
A/Pr Michael Kershaw
金额：
$ 19.22万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2007
资助国家：
澳大利亚
起止时间：
2007-01-01 至 2009-12-31
项目状态：
已结题

来源：
https://researchdata.edu.au/generating-tumour-specific-cancer-therapy/81615
关键词：
Generating Tumour Specific Dendritic Cells

项目摘要

Therapies using the immune system are showing promise for cancer treatment, particularly for melanoma, but complete durable responses are few and improvements are needed. We believe that such immunotherapies, in their current form, fail to sufficiently mimic a natural immune reaction to disease, and therefore fall short of effectively controling cancer. In particular, an alarm (danger signal) is not produced within tumour as it would be when the body is challenged by infectious agents. Such danger signals are critical for the immune system to respond effectively and for white blood cells of the immune system to find their way to the disease organism and eliminate it. The strongest danger signals are produced by a type of white blood cell known as a dendritic cell (DC). These cells detect infectious agents and produce biochemical alarm molecules that alert the entire immune system to the danger resulting in powerful action against the disease. However, tumours are really just a part of our own body and no danger signal is produced. It is our aim to use genetic modification to make DC see tumours as a threat and produce danger signals. These gene-modified DC either alone, or in combination with other immunotherapies, may lead to destruction of tumours.

使用免疫系统的疗法显示出癌症治疗的前景，特别是对于黑色素瘤，但完全持久的反应很少，需要改进。我们认为，这种免疫疗法，以其目前的形式，未能充分模拟对疾病的自然免疫反应，因此无法有效控制癌症。特别是，警报（危险信号）不会在肿瘤内产生，因为当身体受到传染性病原体的挑战时会产生警报。这种危险信号对于免疫系统有效地作出反应以及免疫系统的白色血细胞找到它们的途径到达疾病生物体并消灭它至关重要。最强的危险信号是由一种称为树突状细胞（DC）的白色血细胞产生的。这些细胞检测感染因子，并产生生化警报分子，警告整个免疫系统的危险，从而对疾病采取强有力的行动。然而，肿瘤实际上只是我们身体的一部分，不会产生危险信号。我们的目标是利用基因改造使DC将肿瘤视为威胁并产生危险信号。这些基因修饰的DC无论是单独使用，还是与其他免疫疗法联合使用，都可能导致肿瘤的破坏。