An integrated approach for the efffective adoptive immunotherapy of cancer

癌症有效过继免疫治疗的综合方法

• 批准号: nhmrc : 508968
• 负责人: A/Pr Michael Kershaw
• 金额: $ 31.21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-integrated-approach-immunotherapy-cancer/99454
• 关键词: integrated; approach; efffective; adoptive; immunotherapy

Killer T lymphocytes can penetrate tumors and their transfer into cancer patients has demonstrated some encouraging results, but this form of immunotherapy remain ineffective in most cancer patients. We propose to improve the tumor trafficking and anti-tumor activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells. The outcomes of this project will validate this novel approach for treatment of cancer patients.

杀伤性T淋巴细胞可以穿透肿瘤，它们转移到癌症患者体内已经证明了一些令人鼓舞的结果，但这种形式的免疫疗法在大多数癌症患者中仍然无效。我们建议通过基因工程改造杀伤细胞的蛋白质，使其能够识别和摧毁癌细胞，从而改善杀伤细胞的肿瘤运输和抗肿瘤活性。该项目的结果将验证这种治疗癌症患者的新方法。