Generation of Complex Responses in Retinal Ganglion Cells

视网膜神经节细胞中复杂反应的产生

• 批准号: nhmrc : 351538
• 负责人: A/Pr Nathan Hart
• 金额: $ 32.71万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generation-complex-responses-ganglion-cells/94571
• 关键词: Generation; Complex; Responses; Retinal; Ganglion

The retinal ganglion cells, whose axons form the optic nerve, comprise numerous distinct types, which respond to visual stimuli in either a simple or complex manner. The project will investigate how the complex responses of the direction-selective ganglion cells (DSGCs) and the local-edge-detector ganglion cells (LEDs) are generated. It appears that the retinal neurons providing inhibitory input to DSGCs and LEDs use different neurotransmitters, and the project will investigate how this shapes the response properties of the ganglion cells. This will be done both by recording the visually evoked responses of the ganglion cells in an isolated preparation of the retina and by using two-photon laser-scanning microscopy to functionally image the neuronal interactions between the neurons that inhibit the DSGCs.

视网膜神经节细胞的轴突形成视神经，包括许多不同类型的细胞，它们以简单或复杂的方式对视觉刺激做出反应。该项目将研究方向选择性神经节细胞(DSGCs)和局部边缘检测神经节细胞(LED)的复杂反应是如何产生的。似乎为DSGCs和LED提供抑制输入的视网膜神经元使用不同的神经递质，该项目将研究这如何影响神经节细胞的反应特性。这将通过记录分离的视网膜准备中的神经节细胞的视觉诱发反应和使用双光子激光扫描显微镜来功能性地成像抑制DSGCs的神经元之间的神经元相互作用来完成。