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T Cell Immune Responses To HIV And Other Pathogens

T Cell Immune Responses To HIV And Other Pathogens
T 细胞对 HIV 和其他病原体的免疫反应
批准号：
7184263
负责人：
Daniel Cesar Douek
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7184263
关键词：
AIDS vaccinesHIV infectionsT cell receptorcellular immunityclinical trialscytotoxic T lymphocyteenzyme linked immunosorbent assayflow cytometryhelper T lymphocytehost organism interactionhuman immunodeficiency virus 1human subjectimmune responseimmunoregulationlymphocyte proliferationmicroorganism immunologypatient oriented researchpolymerase chain reactionstainingsvirus antigenvirus geneticsvirus infection mechanismvirus replication

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中文摘要
翻译
我们还没有完全确定与HIV复制的免疫控制相关的免疫反应。为了开发一种有效的疫苗，我们需要更好地了解可能控制艾滋病毒的反应，以及这些防御可能失败的原因。本研究检测了自然感染受试者对HIV的T细胞免疫反应。它将这些反应与针对其他病毒和非病毒性病原体产生的反应进行比较，以确定免疫反应成功或失败的机制。
英文摘要
We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.
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Host Genomic Factors in Infectious Disease Susceptibility
T Cell Immune Responses To HIV And Other Pathogens
T Cell Immune Responses To HIV And Other Pathogens
Immune Responses To HIV And Other Pathogens
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