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The Thymus In HIV Infection And Immune Reconstitution

The Thymus In HIV Infection And Immune Reconstitution
HIV 感染和免疫重建中的胸腺
批准号：
6684267
负责人：
Daniel Cesar Douek
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6684267
关键词：
AIDS therapy HIV infections developmental immunology enzyme linked immunosorbent assay flow cytometry human subject interleukin 7 organ culture pathologic process patient oriented research polymerase chain reaction thymus

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中文摘要
翻译
在接受HAART治疗的HIV感染患者中，T细胞数量和功能的重建率各不相同。理解T细胞恢复的机制对于设计未来改善T细胞重建的策略将是重要的。胸腺是负责从骨髓来源的前体产生具有广泛免疫库的新的幼稚T细胞的器官。IL-7是对胸腺和初始T细胞具有直接作用的细胞因子。本研究探讨了胸腺在HIV感染和免疫重建中的作用，以及IL-7如何影响这一作用。
英文摘要
In HIV-infected patients treated with HAART, there are variable rates of reconstitution of T cell numbers and function. An understanding of the mechanisms underlying the recovery of T cells will be important for the design of future strategies to improve T cell reconstitution. The thymus is the organ responsible for producing new naive T cells with a broad immune repertoire from bone marrow-derived precursors. IL-7 is a cytokine that has direct effects upon the thymus and naive T cells. This study examines the role of the thymus in HIV infection and immune reconstitution, and how IL-7 can affect that role.
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会议论文
T Cell Immune Responses To HIV And Other Pathogens
Host Genomic Factors in Infectious Disease Susceptibility
T Cell Immune Responses To HIV And Other Pathogens
T Cell Immune Responses To HIV And Other Pathogens
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