Clonal Dynamics of HIV/SIV-specific T cells

通过病毒抗原结构突变逃避适应性t细胞免疫是SIV/HIV感染发病机制的主要特征，也是抗逆转录病毒疫苗开发的主要障碍。然而，这种现象在t细胞受体（TCR）抗原界面的分子决定因素是未知的。本研究探讨了在单个T细胞克隆水平上，T细胞反应如何与病毒抗原抗原抗原结构的变化相互作用。通过病毒抗原结构突变逃避适应性t细胞免疫是SIV/HIV感染发病机制的主要特征，也是抗逆转录病毒疫苗开发的主要障碍。然而，这种现象在t细胞受体（TCR）抗原界面的分子决定因素是未知的。本研究探讨了在单个T细胞克隆水平上，T细胞反应如何与病毒抗原抗原抗原结构的变化相互作用。

Escape from adaptive T-cell immunity through mutation of viral antigenic structure is a cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to antiretroviral vaccine development. However, the molecular determinants of this phenomenon at the T-cell receptor (TCR)antigen interface are unknown. This study examines how the T cell response interacts with the changing antigenic structure of viral antigens at the level of individual T cell clones.Escape from adaptive T-cell immunity through mutation of viral antigenic structure is a cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to antiretroviral vaccine development. However, the molecular determinants of this phenomenon at the T-cell receptor (TCR)antigen interface are unknown. This study examines how the T cell response interacts with the changing antigenic structure of viral antigens at the level of individual T cell clones.