PREMISE: Pandemic Response Repository through Microbial and Immune Surveillance and Epidemiology

前提是一个积极主动的大流行预防计划，以建立一个有形的免疫生物学对策储备，以加快对全球大流行威胁的反应 Premise评估目标人群中针对已知和新病毒的免疫反应 Premise将这些数据转化为诊断、治疗和预防资产 交付成果： 早期检测和诊断化验的试剂和数据资源 具有预防和治疗潜力的单抗 适用于疫苗发现和开发的免疫原 活动： 对人畜共患宿主和有症状的人类进行基因分析，以发现病原体 发展高通量、多元化的血清学和细胞免疫分析 在具有战略靶向性的队列中识别针对已知和新病毒的抗原特异性和交叉反应免疫反应 建立和扩大国内实验室化验能力

PREMISE is a proactive pandemic preparedness program to establish a stockpile of tangible immunobiological countermeasures to accelerate the response to pandemic threats globally PREMISE assesses immune responses against known and novel viruses in targeted human populations PREMISE translates these data into diagnostic, therapeutic and prophylactic assets Deliverables: Reagent and data resources for early detection and diagnostic assays Monoclonal antibodies with potential for prevention and therapy Immunogens suitable for vaccine discovery and development Activities: Conduct genetic analysis of zoonotic reservoirs and symptomatic humans for pathogen discovery Develop high throughput, multiplexed serologic and cellular immune assays Identify antigen-specic and cross-reactive immune responses to known and novel viruses in strategically targeted cohorts Establish and expand in-country laboratory assay capabilities