Engineering Cupriavidus necator for gram-scale production of 1,2-propanediol from CO2

工程化 Cupriavidus necator 用于从 CO2 克级生产 1,2-丙二醇

• 批准号: 2882935
• 金额: --
• 依托单位: Northumbria University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2882935
• 关键词: Engineering; Cupriavidus; necator; gram; scale

The project will combine metabolic engineering strategies (systems and synthetic biology) and fermentation process in screening and characterising different enzymes suitable for the proposed pathways, draw insights into the metabolism and propose optimised processes for stable and continuous 1,2-PDO production from CO2 in gram scale. Student will be trained in metabolic pathway analysis (autotrophic, heterotrophic pathways), bioinformatics, to identify optimal metabolic routes, determining pathways or genes to be attenuated or overexpressed aiding the product formation. Student will engage in workshops, national and international conferences highlighting the results, interacting with wider scientific community and will work with multidisciplinary team of researchers at Northumbria University and P&G

该项目将结合代谢工程策略（系统和合成生物学）和发酵过程，以筛选和表征适合拟议途径的不同酶，吸引对代谢的见解，并提出优化的过程，以实现稳定且连续的1,2-PDO生产，以革兰氏量表以二氧化碳的量表为单位。学生将接受代谢途径分析（自养，异养途径），生物信息学的培训，以识别最佳的代谢路线，确定要减弱或过表达辅助产物形成的途径或基因。学生将参加研讨会，国家和国际会议，以强调结果，与更广泛的科学界互动，并将与诺森比亚大学和P＆G的多学科研究人员合作