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Video Rate OCT for Evaluating Glaucoma

用于评估青光眼的视频速率 OCT

基本信息

批准号：
7321203
负责人：
Boris Hyle Park
金额：
$ 76.2万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2008-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7321203
关键词：
3-Dimensional Affect Algorithms American Astigmatism Blindness Characteristics Clinical Collection Data Data Set Depth Detection Diagnosis Early Diagnosis Early treatment Enrollment Eye Eye diseases Glaucoma Grant Histology Histopathology Human Image Imaging Techniques Imaging technology Institutes Invasive Lasers Lateral Lighting Maps Measures Methods Motion Multivariate Analysis Nerve Fibers Noise Numbers Ocular Hypertension Onset of illness Open-Angle Glaucoma Ophthalmoscopy Optic Disk Optical Coherence Tomography Optics Other Imaging Modalities Pathology Patients Pattern Photography Physiologic pulse Population Preventive Pulse taking Rate Reproducibility Resolution Retina Retinal Ganglion Cells Scanning Signal Transduction Standards of Weights and Measures Structure System Techniques Technology Testing Therapeutic Intervention Thick Time United States Visual Fields adaptive optics base clinical Diagnosis follow-up improved in vivo instrument light scattering polarimetry prevent programs retinal nerve fiber layer tomography

项目摘要

DESCRIPTION (provided by applicant): Glaucoma is the second leading cause of blindness worldwide. In the United States, approximately 2.5 million Americans are affected by this potentially blinding eye disease. Optical coherence tomography (OCT) is a non-invasive imaging technique allowing high-resolution cross-sectional imaging of the human retina. Under the previous grant period, we have developed an OCT system that outperforms existing commercially available systems by orders of magnitude, enabling video rate cross-sectional and 3-dimensional volumetric imaging of the human retina in vivo. Since glaucoma causes optic nerve head (ONH) cupping and retinal nerve fiber layer (RNFL) thinning prior to loss of vision, optical coherence tomography (which measures both ONH structure and nerve fiber layer thickness) could enable early detection of glaucoma prior to permanent loss of vision. This earlier detection would enable earlier treatment to prevent permanent loss of vision. Since glaucoma also causes progressive ONH changes and nerve fiber layer thinning prior to further loss of vision, optical coherence tomography could enable earlier detection of glaucomatous progression prior to further permanent loss of vision, enabling more aggressive preventive treatment. Current clinical techniques only allow diagnosis of glaucomatous loss of vision after up to half of the retinal ganglion cells are permanently lost. In this grant period we propose to evaluate various methods to analyze the ONH and RNFL thickness in a population of 100 glaucoma patients and 50 ocular hypertension patients and determine characteristic features associated with glaucoma in RNFL thickness maps centered on the ONH. The characteristic features will be correlated with standard technologies to evaluate glaucoma. Patients will be imaged at enrollment in the study and at one year follow up. We will determine the reliability and reproducibility of ONH parameters and RNFL thickness determinations. The results of this study will quantify the changes in the ONH and RNFL that can be detected by our OCT system and will provide the necessary framework for a large multi-center longitudinal trial which would evaluate if OCT's detection of ONH and nerve fiber layer changes can precede current clinical techniques' (i.e. GDx, HRT, OCT3, Humphrey visual field, etc) detection of glaucoma and vision loss.

描述(申请人提供)：青光眼是全球第二大致盲原因。在美国，大约有250万美国人受到这种潜在的致盲眼病的影响。光学相干层析成像(OCT)是一种非侵入性成像技术，可以对人类视网膜进行高分辨率的横断面成像。在之前的授权期内，我们开发了一种OCT系统，其性能比现有的商业系统高出一个数量级，能够在活体内对人类视网膜进行视频率横断面和三维体积成像。由于青光眼会在失明前引起视神经头(ONH)杯状和视网膜神经纤维层(RNFL)变薄，光学相干断层扫描(ONH结构和神经纤维层厚度)可以在永久性失明之前及早发现青光眼。这种早期检测将使早期治疗成为可能，以防止永久性视力丧失。由于青光眼还会在进一步丧失视力之前导致进行性ONH改变和神经纤维层变薄，光学相干断层扫描可以在进一步永久性丧失视力之前更早地检测到青光眼进展，从而能够进行更积极的预防性治疗。目前的临床技术只能在多达一半的视网膜神经节细胞永久性丧失后才能诊断为青光眼视力丧失。在这一资助期间，我们建议评估各种方法，以分析100名青光眼患者和50名高眼压患者的ONH和RNFL厚度，并在以ONH为中心的RNFL厚度图中确定与青光眼相关的特征。这些特征将与评估青光眼的标准技术相关联。患者将在参加研究时和一年的随访中进行成像。我们将确定ONH参数和RNFL厚度测定的可靠性和重复性。这项研究的结果将量化我们的OCT系统可以检测到的ONH和RNFL的变化，并将为一项大型多中心纵向试验提供必要的框架，该试验将评估OCT对ONH和神经纤维层变化的检测是否可以先于目前的临床技术(如GDX、HRT、Oct3、Humphrey视野等)检测青光眼和视力丧失。