Genetic dissection of the biogenesis and function of type IV fimbriae of Pseudomonas aeruginosa

铜绿假单胞菌 IV 型菌毛的生物起源和功能的遗传解析

• 批准号: nhmrc : 143054
• 负责人: A/Pr Cynthia Whitchurch
• 金额: $ 27.18万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-dissection-biogenesis-pseudomonas-aeruginosa/94999
• 关键词: Genetic; dissection; biogenesis; function; type

Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. This pathogen, and a number of other important infectious bacteria use surface filaments, called fimbriae, like grappling hooks to attach to the cells of the body and to move across host tissues. These fimbriae are produced in response to environmental conditions, and are assembled by a process that is also used in the export of toxins and other pathogenic molecules. This project will characterise genes which specify and control this system, as a means to design better treatments against such bacteria, many of which are resistant to antibiotic treatment.

铜绿假单胞菌是一种常见的细菌，其导致患有囊性纤维化、AIDS或遭受严重烧伤或正在接受癌症化疗的个体的严重危及生命的感染。这种病原体和其他一些重要的感染性细菌使用表面细丝，称为菌毛，像抓钩一样附着在身体细胞上并在宿主组织中移动。这些菌毛是根据环境条件产生的，并通过一种也用于输出毒素和其他致病分子的过程进行组装。该项目将研究指定和控制该系统的基因，作为设计更好的治疗方法来对抗这些细菌的手段，其中许多细菌对抗生素治疗具有抗药性。