Characterisation of extracellular DNases of Pseudomonas aeruginosa and their contribution to disease

铜绿假单胞菌胞外 DNA 酶的表征及其对疾病的贡献

• 批准号: nhmrc : 491130
• 负责人: A/Pr Cynthia Whitchurch
• 金额: $ 27.91万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-extracellular-dnases-contribution-disease/77663
• 关键词: Characterisation; extracellular; DNases; Pseudomonas; aeruginosa

The bacterium Pseudomonas aeruginosa causes a number of serious diseases of humans particularly of immunocompromised patients. We have found that this bacterium secretes enzymes that have the ability to digest DNA. This proposal aims to work out how this bacterium uses these enzymes to infect human tissues and escape killing by immune cells. The results from this study will help to determine if these proteins may be used as targets for the development of new anti-infective drugs.

铜绿假单胞菌（Pseudomonasaeruginosa）引起许多严重的人类疾病，特别是免疫功能低下的患者。我们发现这种细菌分泌的酶具有消化DNA的能力。这项提案旨在研究这种细菌如何利用这些酶感染人体组织并逃避免疫细胞的杀伤。这项研究的结果将有助于确定这些蛋白质是否可用作开发新的抗感染药物的靶点。