Genetic dissection of biofilm development by non-typeable Haemophilus influenzae

不可分型流感嗜血杆菌生物膜发育的基因剖析

• 批准号: nhmrc : 491126
• 负责人: A/Pr Cynthia Whitchurch
• 金额: $ 27.91万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-dissection-biofilm-haemophilus-influenzae/81138
• 关键词: Genetic; dissection; biofilm; development; non

The bacterial pathogen non-typeable Haemophilus influenzae (NTHi) is a common cause of chronic infections of the middle ear and of the airways of patients suffering cystic fibrosis, or chronic obstructive pulmonary disease (COPD). These infections are associated with bacterial biofilms that are significantly resistant to both antibiotics and immune defences. This project aims to characterise the process of NTHi biofilm development so that novel diagnostic tools and therapeutics can be developed.

细菌病原体不可分型流感嗜血杆菌（NTHi）是囊性纤维化或慢性阻塞性肺疾病（COPD）患者中耳和气道慢性感染的常见原因。这些感染与细菌生物膜有关，这些生物膜对抗生素和免疫防御都有明显的抵抗力。该项目旨在描述NTHi生物膜发展的过程，以便开发新的诊断工具和治疗方法。