Analysis of a chemosensory complex that controls twitching motility and virulence in Pseudomonas aeruginosa

控制铜绿假单胞菌抽搐运动和毒力的化学感应复合物的分析

• 批准号: nhmrc : 334076
• 负责人: A/Pr Cynthia Whitchurch
• 金额: $ 23.09万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-chemosensory-complex-pseudomonas-aeruginosa/82223
• 关键词: Analysis; chemosensory; complex; controls; twitching

Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. Infection by this pathogen requires the controlled expression of a large number of virulence factors including extracellular enzyme, toxins and structures for the attachment and colonisation of host tissues. We have identified a complex multicomponent regulatory system which coordinates the expression of many of the virulence determinants of this pathogen. This project aims to dissect the intermolecular interactions and signalling events which input into, occur within, and output from this regulatory system. This knowledge will provide a platform for developing rational strategies for the production of new antimicrobials for fighting infections by this and related pathogens.

铜绿假单胞菌是一种常见的细菌，其导致患有囊性纤维化、AIDS或遭受严重烧伤或正在接受癌症化疗的个体的严重危及生命的感染。这种病原体的感染需要大量毒力因子的受控表达，包括胞外酶、毒素和用于附着和定殖宿主组织的结构。我们已经确定了一个复杂的多组分调节系统，协调表达的许多毒力决定因素的这种病原体。本计画旨在剖析分子间的相互作用和信号事件，这些事件的输入、发生和输出都来自这个调控系统。这些知识将为制定合理的战略提供一个平台，以生产新的抗菌剂来对抗这种和相关病原体的感染。