Disability in Valued Life Activities in Persons with Rheumatoid Arthritis

类风湿关节炎患者有价值的生活活动的障碍

• 批准号: 7277219
• 负责人: Patricia P Katz
• 金额: $ 40.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277219
• 关键词: Activities of Daily Living; Area; Arthralgia; Arthritis; Articular Range of Motion; Behavioral; Complex; Condition; Cross-Sectional Studies; Development; Education; Environmental Risk Factor; Frequencies; Friends; Health; Health Status; Hobbies; Housekeeping; Individual; Interview; Lead; Leisure Activities; Light; Link; Maintenance; Measures; Mediating; Modeling; Modification; Performance; Persons; Play; Principal Investigator; Process; Psychological Factors; Quality of life; Questionnaires; Range; Reporting; Research; Rheumatoid Arthritis; Risk; Risk Factors; Self Care; Self-Help Devices; Social isolation; Social support; Study models; Surveys; Swelling; Symptoms; Telephone Interviews; Therapeutic; Time; Transportation; Value of Life; Well in self; Work; Writing; base; community living; depressive symptoms; disability; experience; help-seeking behavior; improved; instrument; instrumental activity of daily living; joint stiffness; mathematical model; optimism; programs; psychologic; psychological distress; psychological outcomes; satisfaction; social

DESCRIPTION (provided by applicant): This project will describe disability in valued life activities (VLAs) among persons with rheumatoid arthritis (RA), as well as factors associated with maintenance of those activities and factors that may protect against negative psychological outcomes following VLA disability. The same physical manifestations of RA that may cause difficulty in mobility or in performing a self-care activity may also cause difficulty in more complex, discretionary activities such as hobbies or socializing with friends. The wide range of activities that individuals find meaningful or pleasurable, above and beyond activities necessary for survival or self-sufficiency, is what we term "valued life activities". Performance of VLAs appears to be linked to psychological well-being and satisfaction with function. Although loss of VLAs has been found to be a risk factor for the onset of depressive symptoms, effects of difficulties in VLA performance are not known. Also, many individuals who lose the ability to perform VLAs do not develop depressive symptoms; factors that protect individuals from psychological distress after VLA disability have not been identified. This study will estimate VLA disability and identify factors associated with maintenance of VLAs, psychological outcomes of VLA disability, and factors associated with maintenance of psychological well-being after VLA disability, building on the Verbrugge and Jette disablement process model. Subjects will be queried about these topics in annual telephone interviews. Items to assess VLA disability and psychological outcomes will be included in the interview, as well as questions about potential risk and protective factors for VLA disability and psychological distress. These items will consist of existing scales and survey items when available, and items developed specifically for this study. Analyses based on the study model (Figure 1) will focus on 3 major areas: (1) description of VLA disability among individuals with RA over a 5-year period, (2) description of psychological outcomes of VLA disability, and (3) identification of factors associated with maintenance of VLAs and maintenance of psychological well-being after VLA disability. Mathematical models will be developed to describe these relationships in the context of the study model, using both cross-sectional and longitudinal analyses. The findings from this study will provide information that may help minimize VLA disability and the psychological distress that might result from VLA disability, thereby improving quality of life of persons with RA.

描述（由申请人提供）：本项目将描述类风湿性关节炎（RA）患者在有价值的生命活动（VLA）方面的残疾，以及与维持这些活动相关的因素，以及可能防止VLA残疾后产生负面心理后果的因素。可能导致行动困难或进行自我护理活动的RA的相同身体表现也可能导致更复杂的自主活动（如爱好或与朋友社交）的困难。除了生存或自给自足所必需的活动之外，个人认为有意义或令人愉快的广泛活动就是我们所说的“有价值的生活活动”。VLA的表现似乎与心理健康和功能满意度有关。虽然已发现VLA丧失是抑郁症状发作的一个危险因素，但VLA表现困难的影响尚不清楚。此外，许多失去VLA能力的人不会出现抑郁症状; VLA残疾后保护个人免受心理困扰的因素尚未确定。本研究将评估VLA残疾，并确定与VLA维持相关的因素，VLA残疾的心理结局，以及与VLA残疾后维持心理健康相关的因素，建立在Verbrugge和Jette残疾过程模型的基础上。受试者将在年度电话访谈中被询问这些主题。评估VLA残疾和心理结局的项目将包括在访谈中，以及关于VLA残疾和心理困扰的潜在风险和保护因素的问题。这些项目将包括现有的量表和调查项目（如有），以及专门为本研究开发的项目。基于研究模型的分析（图1）将集中在3个主要领域：（1）描述5年内RA患者的VLA残疾，（2）描述VLA残疾的心理结局，（3）确定与VLA残疾后维持VLA和维持心理健康相关的因素。将开发数学模型来描述这些关系的研究模型的背景下，使用横截面和纵向分析。这项研究的结果将提供信息，可能有助于尽量减少VLA残疾和可能导致VLA残疾的心理困扰，从而提高RA患者的生活质量。

项目成果

Subclinical disability in valued life activities among individuals with rheumatoid arthritis.

• DOI: 10.1002/art.24110
• 发表时间: 2008-10-15
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Katz, Patricia;Morris, Anne;Yelin, Edward
• 通讯作者: Yelin, Edward

Patient-reported outcomes following biologic therapy in a sample of adults with rheumatoid arthritis recruited from community-based rheumatologists.

• DOI: 10.1002/art.24511
• 发表时间: 2009-05-15
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Katz, Patricia;Yelin, Edward;Patel, Vaishali;Huang, Ring-Yue;Chiou, Chiun-Fang
• 通讯作者: Chiou, Chiun-Fang

Patterns of psychosocial risk and long-term outcomes in rheumatoid arthritis.

• DOI: 10.1080/13548500801927113
• 发表时间: 2008-10-01
• 期刊: Psychology, health & medicine
• 作者: Morris, Anne;Yelin, Edward H;Katz, Patricia P
• 通讯作者: Katz, Patricia P

Development and validation of a short form of the valued life activities disability questionnaire for rheumatoid arthritis.

• DOI: 10.1002/acr.20617
• 发表时间: 2011-12
• 期刊: ARTHRITIS CARE & RESEARCH
• 影响因子: 4.7
• 作者: Katz, Patricia P.;Radvanski, Diane C.;Allen, Diane;Buyske, Steven;Schiff, Samuel;Nadkarni, Anagha;Rosenblatt, Lisa;Maclean, Ross;Hassett, Afton L.
• 通讯作者: Hassett, Afton L.