Body Composition and Disability in RA and SLE

这项研究的主要目的是评估身体成分在功能性发育中的作用。 类风湿性关节炎(RA)和系统性红斑狼疮(SLE)的模仿和残疾，在 这是一个公认的残疾模式的背景。使用这一模式将促进更大的 了解身体成分在残疾发展中的作用，同时考虑到其他 疾病、治疗、人口统计、心理社会和行为因素，可能有助于或保护 因残疾而死亡。该项目还代表了首次尝试描述患有残疾的人的残疾 系统性红斑狼疮涵盖了广泛的生活活动，使用了残疾的“有价值的生活活动”模式。具体目标 目的是：(1)研究身体成分在系统性红斑狼疮患者功能缺陷和残疾发展中的作用 和RA，使用现有的残疾模型；(2)确定与身体相互作用的风险和保护因素 构成功能缺陷和残疾的发展，或维持功能和 避免残疾，在类风湿性关节炎和系统性红斑狼疮中；以及(3)估计广泛的残疾患病率和发病率 一大群系统性红斑狼疮患者的生活活动范围。拟议研究的对象将是 现有的加州大学旧金山分校RA小组和狼疮结果研究(LOS)的成员。现有的研究方案 包括到2008年对这些群体进行年度电话访谈，并提议在#年再增加两年 此应用程序的方法核心。拟议的研究将在此基础上增加具体项目 对年度电话采访的措施，并在加州大学旧金山分校综合医院增加了两项面对面评估 临床研究中心(GCRC)，用于每个队列中的受试者子集。在GCRC的访问中，我们将 进行身体成分评估，进行肌肉力量和身体功能测试， 获取血液样本以测量炎症和其他标志物，获得习惯性的估计 体力活动，并进行认知功能评估。分析，访谈和家访相结合 数据，将重点放在3个主要领域-(1)描述两个队列中的身体成分发现，(2)估计 2个队列中身体成分与功能受限和残疾的关系；以及(3) 确定可能改变或调节身体成分和 功能受限或残疾。分析还将确定自我报告的信息之间的相关性 根据访谈数据(例如，根据自我报告的身高和体重计算的身体质量指数) 从GCRC的评估中收集。这项研究的发现将提供有助于 确定患有类风湿关节炎和系统性红斑狼疮的人可能是残疾的最大风险，并估计 残疾发展的干预因素。

The overarching aim of this study is to estimate the role of body composition in the development of functional imitations and disability in both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), within the context of a well-established model of disablement. Use of this model will facilitate a greater understanding of the role of body composition in the development of disability, taking into account other disease, therapeutic, demographic, psychosocial, and behavioral factors that may contribute to or protect from disability. This project also represents the first attempt to characterize disability among persons with SLE across a wide range of life activities using the "valued life activities" model of disability. Specific aims are to: (1) examine the role of body composition in development of functional limitations and disability in SLE and RA, using an existing model of disablement; (2) identify risk and protective factors that interact with body composition in the development of functional limitations and disability, or the maintenance of function and avoidance of disability, in RA and SLE; and (3) estimate the prevalence and incidence of disability in a wide range of life activities in a large group of individuals with SLE. Subjects for the proposed study will be members of the existing UCSF RA Panel and Lupus Outcomes Study (LOS). Existing study protocols include annual telephone interviews with the cohorts through 2008, with an additional two years proposed in the Methodology Core of this application. The proposed study will build upon this by adding project-specific measures to the annual telephone interviews, and adding two in-person assessments at the UCSF General Clinical Research Center (GCRC) for a subset of subjects from each cohort. At the GCRC visit, we will conduct an assessment of body composition, conduct testing of muscle strength and physical function, obtain blood samples for measurement of inflammatory and other markers, obtain an estimate of habitual physical activity, and perform a cognitive function evaluation. Analyses, combining interview and home visit data, will focus on 3 major areas - (1) describing body composition findings in the 2 cohorts, (2) estimating the relationship between body composition and functional limitations and disability in the 2 cohorts; and (3) identification of factors that may modify or mediate the relationship between body composition and either functional limitations or disability. Analyses will also identify the correlation between self-reported information from interview data (e.g., body mass index calculated from self-reported height and weight) with that gathered from the GCRC assessment. The findings from this study will provide information that can assist in identifying individuals with RA and SLE who may be at greatest risk of disability, and estimating the effect of intervening factors on the development of disability.