课题基金 / 基金详情

Regulatory Circuits and Virulence in Candida albicans

Regulatory Circuits and Virulence in Candida albicans
白色念珠菌的调节回路和毒力
批准号：
7164436
负责人：
ALEXANDER D JOHNSON
金额：
$68.05万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-03-01 至 2011-02-28
来源：
https://reporter.nih.gov/project-details/7164436
关键词：
RegulatoryCircuitsVirulenceCandidaalbicans

项目摘要

项目成果

ALEXANDER D JOHNSON的其他基金

相似基金

相关文献

中文摘要
翻译
描述(申请人提供)：白色念珠菌是哺乳动物消化道中的一种共生生物。它也是最常见的人类真菌病原体，可引起黏膜和全身感染，特别是在免疫功能低下的人中。这项建议涵盖了念珠菌的六个不同方面的研究，其中五个方面与发病机制有关。(第六个尚未研究。)这些区域是(1)可逆的胚芽孢子到花丝形态的转变，(2)菌丝顶端细胞的专化，(3)白色-不透明的切换，(4)交配，(5)‘毒力’基因的鉴定，(6)调节的RNA剪接在毒力中的可能作用。
英文摘要
DESCRIPTION (provided by applicant): The yeast Candida albicans is found as a commensal organism in the digestive tract of mammals. It is also the most common human fungal pathogen, causing both mucosal and systemic infections, particularly in immunocompromised people. This proposal covers studies of six different aspects of Candida five of which have been implicated in aspects of pathogenesis. (The sixth has not yet been studied.) These areas are (1) the reversible blastospore to filament morophologica transitions, (2) specialization of hyphal tip cells, (3) white-opaque switching, (4) mating, (5) the identification of 'virulence' genes and, (6) the possible role of regulated RNA splicing in virulence.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
海外基金