Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
批准号:
7767722
负责人:
ALEXANDER D JOHNSON
金额:
$61.86万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-01 至 2011-11-30
关键词:
AreaBindingCandidaCandida albicansCellsChromansCollaborationsEnvironmentFilamentGastrointestinal tract structureGene TargetingGenesGenetic ScreeningGenomeGoalsGrowthHumanImmunocompromised HostImmunoprecipitationInfectionKnock-outLaboratoriesMammalsMolecularMusOrganismPartner in relationshipPathogenesisPatternProceduresPropertyRNA SplicingRoleSaccharomyces cerevisiaeSchemeSystemic infectionVirulenceYeastsbasecell typedesignfitnessmouse modelpathogenprograms
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The yeast Candida albicans is found as a commensal organism in the digestive tract of mammals. It is also
the most common human fungal pathogen, causing both mucosal and systemic'infections, particularlyin
immunocompromised people. This proposal covers studies of six different aspects of Candida five of which
have been implicated in aspects of pathogenesis. (The sixth has not yet been studied.) These areas are (1)
the reversible blastospore to filament morophologica transitions, (2) specialization of hyphal tip cells, (3)
white-opaque switching, (4) mating, (5) the identification of 'virulence' genes and, (6) the possible role of
regulated RNA splicing in virulence.
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会议论文
Regulatory Circuits and Virulence in Candida albicans
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批准号:8975112
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项目类别:
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资助金额:$71.34万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:8589572
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项目类别:
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资助金额:$71.34万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:8232963
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项目类别:
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资助金额:$68.7万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:8369860
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项目类别:
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资助金额:$67.06万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8038140
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项目类别:
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资助金额:$32.88万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8197358
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项目类别:
-
资助金额:$30.11万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8586244
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项目类别:
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资助金额:$36.71万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8384866
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项目类别:
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资助金额:$34.67万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:7404623
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项目类别:
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资助金额:$17.24万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:6760497
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项目类别:
-
资助金额:$18.17万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:7204157
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项目类别:
-
资助金额:$17.59万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
SEARCH FOR STRUCTURE-SPECIFIC DNA NUCLEASE
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批准号:6979526
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项目类别:
-
资助金额:$0.36万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:7031544
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项目类别:
-
资助金额:$18.12万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:6865521
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项目类别:
-
资助金额:$18.94万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7028471
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项目类别:
-
资助金额:$68.63万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:6511324
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项目类别:
-
资助金额:$51.02万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:6703665
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项目类别:
-
资助金额:$52.73万
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财政年份:2001
-
负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:6848682
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项目类别:
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资助金额:$54.82万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7568750
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项目类别:
-
资助金额:$63.83万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7164436
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项目类别:
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资助金额:$68.05万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
-
依托单位:
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