Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
批准号:
8589572
负责人:
ALEXANDER D JOHNSON
金额:
$71.34万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-12-01 至 2016-11-30
关键词:
AddressAffectAntifungal AgentsBar CodesBiochemicalBiologicalCandida albicansCarbonCarbon DioxideCellsCollectionComplexDNADNA BindingDNA Binding DomainDataDeletion MutationDiseaseDissectionEctopic ExpressionEnvironmentEnvironmental Risk FactorFission YeastFunctional RNAGastrointestinal tract structureGene TargetingGenesGenetic TranscriptionGenomeGoalsHandHeartHeritabilityHomologous GeneHumanImmuneIn VitroIndividualInfectionInjection of therapeutic agentIntercistronic RegionIntestinesKidneyLaboratoriesLeukocytesLifeLinkLiverLongitudinal StudiesModelingMolecularMolecular TargetMonitorMusOpen Reading FramesOrthologous GeneOutputOxygenPartner in relationshipPathogenicityPatientsPhenotypePlayProcessProliferatingProteinsRelative (related person)RoleSaccharomyces cerevisiaeSiteSourceSpleenStructureSymbiosisSystemic infectionTailTemperatureTestingTranscriptVeinsVirulenceWorkYeastsbasefeedingfungusin vitro Assayin vivointerestmutantnovelpathogenprogramstranscriptome sequencing
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The yeast Candida albicans is a normal resident of the human digestive tract. It is also the most common fungal pathogen of humans, causing both mucosal and systemic infections, particularly in immune compromised patients. This proposal seeks to understand how C. albicans orchestrates its many interactions with the host. Our strategy is to approach aspects of commensalism and pathogenicity through dissection of the transcriptional circuitry that controls these processes. Our overarching goal is to understand how C. albicans is specialized to thrive and cause disease in many different environments of the host.
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会议论文
Regulatory Circuits and Virulence in Candida albicans
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批准号:8975112
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项目类别:
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资助金额:$71.34万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:8232963
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项目类别:
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资助金额:$68.7万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:8369860
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项目类别:
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资助金额:$67.06万
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财政年份:2011
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8038140
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项目类别:
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资助金额:$32.88万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8197358
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项目类别:
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资助金额:$30.11万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8586244
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项目类别:
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资助金额:$36.71万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
The transcriptional circuitry controlling biofilm development in Candida albicans
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批准号:8384866
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项目类别:
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资助金额:$34.67万
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财政年份:2010
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:7404623
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项目类别:
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资助金额:$17.24万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:6760497
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项目类别:
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资助金额:$18.17万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:7204157
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项目类别:
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资助金额:$17.59万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
SEARCH FOR STRUCTURE-SPECIFIC DNA NUCLEASE
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批准号:6979526
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项目类别:
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资助金额:$0.36万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:7031544
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项目类别:
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资助金额:$18.12万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Chromosome loss in the fungal pathogen C. albicans
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批准号:6865521
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项目类别:
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资助金额:$18.94万
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财政年份:2004
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7028471
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项目类别:
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资助金额:$68.63万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:6511324
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项目类别:
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资助金额:$51.02万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:6703665
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项目类别:
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资助金额:$52.73万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:6848682
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项目类别:
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资助金额:$54.82万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7568750
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项目类别:
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资助金额:$63.83万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7767722
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项目类别:
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资助金额:$61.86万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:7164436
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项目类别:
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资助金额:$68.05万
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财政年份:2001
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负责人:ALEXANDER D JOHNSON
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依托单位:
海外基金