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Regulatory Circuits and Virulence in Candida albicans

Regulatory Circuits and Virulence in Candida albicans
白色念珠菌的调节回路和毒力
批准号：
8369860
负责人：
ALEXANDER D JOHNSON
金额：
$67.06万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-12-01 至 2016-11-30
来源：
https://reporter.nih.gov/project-details/8369860
关键词：
AddressAffectAntifungal AgentsBar CodesBiochemicalBiologicalCandida albicansCarbonCarbon DioxideCellsCollectionComplexDNADNA BindingDNA Binding DomainDataDeletion MutationDiseaseDissectionEctopic ExpressionEnvironmentEnvironmental Risk FactorFission YeastFunctional RNAGastrointestinal tract structureGene TargetingGenesGenetic TranscriptionGenomeGoalsHandHeartHeritabilityHomologous GeneHumanImmuneIn VitroIndividualInfectionInjection of therapeutic agentIntercistronic RegionIntestinesKidneyLaboratoriesLeukocytesLifeLinkLiverLongitudinal StudiesModelingMolecularMolecular TargetMonitorMusOpen Reading FramesOrthologous GeneOutputOxygenPartner in relationshipPathogenicityPatientsPhenotypePlayProcessProliferatingProteinsRelative (related person)RoleSaccharomyces cerevisiaeSiteSourceSpleenStructureSymbiosisSystemic infectionTailTemperatureTestingTranscriptVeinsVirulenceWorkYeastsbasefeedingfungusin vitro Assayin vivointerestmutantnovelpathogenprogramstranscriptome sequencing

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中文摘要
翻译
描述（由申请人提供）：白色念珠菌是人类消化道的正常居民。它也是人类最常见的真菌病原体，引起粘膜和全身感染，特别是在免疫功能低下的患者中。本文试图了解C。白念珠菌协调了它与宿主的许多相互作用。我们的策略是通过解剖控制这些过程的转录电路来接近细菌的致病性和致病性。我们的首要目标是了解C。白色念珠菌专门在宿主的许多不同环境中生长并引起疾病。
英文摘要
DESCRIPTION (provided by applicant): The yeast Candida albicans is a normal resident of the human digestive tract. It is also the most common fungal pathogen of humans, causing both mucosal and systemic infections, particularly in immune compromised patients. This proposal seeks to understand how C. albicans orchestrates its many interactions with the host. Our strategy is to approach aspects of commensalism and pathogenicity through dissection of the transcriptional circuitry that controls these processes. Our overarching goal is to understand how C. albicans is specialized to thrive and cause disease in many different environments of the host.
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