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Regulatory Circuits and Virulence in Candida albicans

白色念珠菌的调节回路和毒力

基本信息

批准号：
8232963
负责人：
ALEXANDER D JOHNSON
金额：
$ 68.7万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-01 至 2016-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8232963
关键词：
Address Affect Antifungal Agents Bar Codes Biochemical Biological Candida albicans Carbon Carbon Dioxide Cells Collection Complex DNA DNA Binding DNA Binding Domain Data Deletion Mutation Disease Dissection Ectopic Expression Environment Environmental Risk Factor Fission Yeast Functional RNA Gastrointestinal tract structure Gene Targeting Genes Genetic Transcription Genome Goals Hand Heart Heritability Homologous Gene Human Immune In Vitro Individual Infection Injection of therapeutic agent Intercistronic Region Intestines Kidney Laboratories Leukocytes Life Link Liver Longitudinal Studies Modeling Molecular Molecular Target Monitor Mus Open Reading Frames Orthologous Gene Output Oxygen Partner in relationship Pathogenicity Patients Phenotype Play Process Proliferating Proteins RNA Relative (related person)Role Saccharomyces cerevisiae Site Source Spleen Structure Symbiosis Systemic infection Tail Temperature Testing Transcript Veins Virulence Work Yeasts base feeding fungus in vitro Assay in vivo interest mutant novel pathogen programs

项目摘要

DESCRIPTION (provided by applicant): The yeast Candida albicans is a normal resident of the human digestive tract. It is also the most common fungal pathogen of humans, causing both mucosal and systemic infections, particularly in immune compromised patients. This proposal seeks to understand how C. albicans orchestrates its many interactions with the host. Our strategy is to approach aspects of commensalism and pathogenicity through dissection of the transcriptional circuitry that controls these processes. Our overarching goal is to understand how C. albicans is specialized to thrive and cause disease in many different environments of the host. PUBLIC HEALTH RELEVANCE: C. albicans is the most prevalent fungal pathogen of humans. It causes superficial infections in normal humans and life threatening, systemic infections in immune compromised individuals. This proposal seeks to understand how C. albicans regulates its genes so it can survive and proliferate in many environments of its human host. An important component of our work is the identification of virulence genes which, in the long term, will provide molecular targets for new classes of antifungal drugs.

描述（由申请人提供）：白色念珠菌是人类消化道的正常居民。它也是人类最常见的真菌病原体，引起粘膜和全身感染，特别是在免疫功能低下的患者中。本文试图了解C。白念珠菌协调了它与宿主的许多相互作用。我们的策略是通过解剖控制这些过程的转录电路来接近细菌的致病性和致病性。我们的首要目标是了解C。白色念珠菌专门在宿主的许多不同环境中生长并引起疾病。公共卫生相关性：C.白色念珠菌是人类最普遍的真菌病原体。它在正常人中引起浅表感染，在免疫受损的个体中引起危及生命的全身感染。本文试图了解C。白色念珠菌调节其基因，因此它可以在其人类宿主的许多环境中存活和增殖。我们工作的一个重要组成部分是鉴定毒力基因，从长远来看，这将为新型抗真菌药物提供分子靶点。