Genetic Dissection Of Stem Cell Function

干细胞功能的基因剖析

• 批准号: nhmrc : 406676
• 负责人: A/Pr Marnie Blewitt
• 金额: $ 18.45万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-dissection-stem-cell-function/114839
• 关键词: Genetic; Dissection; Stem; Cell; Function

Adult and embryonic stem cells have enormous therapeutic potential. Haemopoietic stem cells have been the most intensely studied and widely used in a therapeutic setting, yet we have only a patchy knowledge of the genes required for their proliferation and survival. I will use classical genetic screens in the mouse to identify genes that regulate stem cell behaviour. I will analyse two existing mutant mouse strains with reduced numbers of haemopoietic stem cells, and execute a novel genetic screen utilising mice with a defect in the self-renewal of adult haemopoietic and neural stem cells, to find mice with a recovered stem cell compartment.

成体和胚胎干细胞具有巨大的治疗潜力。造血干细胞一直是研究最深入、应用最广泛的治疗方法，但我们对其增殖和存活所需的基因知之甚少。我将在小鼠身上使用经典的基因筛选来识别控制干细胞行为的基因。我将分析两个现有的造血干细胞数量减少的突变小鼠品系，并利用成年造血干细胞和神经干细胞自我更新缺陷的小鼠进行一项新的基因筛查，以找到干细胞舱恢复的小鼠。