Investigating new molecular mechanisms that contribute to the establishment of epigenetic silencing

研究有助于建立表观遗传沉默的新分子机制

• 批准号: nhmrc : GNT1140976
• 负责人: A/Pr Marnie Blewitt
• 金额: $ 148.81万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-new-molecular-epigenetic-silencing/1348340
• 关键词: Investigating; new; molecular; mechanisms; contribute

Epigenetic marks are changes made to the DNA which help genes to be switched off in some cells and switched on in others e.g. for elastin to be switched on in skin and off in blood. Epigenetic marks are critical to normal development. We are interested in the genes that are necessary to add epigenetic marks to the DNA and understanding how the many genes involved in this process co-operate at the molecular level to switch genes off.

表观遗传标记是对DNA的改变，有助于基因在某些细胞中关闭，在其他细胞中打开，例如在皮肤中打开弹性蛋白，在血液中关闭。表观遗传标记对正常发育至关重要。我们感兴趣的是在DNA中添加表观遗传标记所必需的基因，并了解参与这一过程的许多基因如何在分子水平上合作以关闭基因。