Screening and characterisation of mammalian epigenetic modifiers

形成一个成年人的所有信息都包含在受精卵的DNA中。发育是通过基因的开启和关闭来实现的，由一种叫做表观遗传修饰因子的蛋白质控制。有时这种方法失败，导致疾病。尽管它们起着至关重要的作用，但我们只有20%的潜在人类表观遗传修饰因子的数据。我将使用新的基于屏幕的技术来发现更多的基因，使我们和其他人能够描述表观遗传学在正常发育和疾病中的作用。

All the information to form an adult is contained in the DNA of the fertilized egg. Development is achieved by turning genes on and off, controlled by proteins called epigenetic modifiers. Sometimes this fails, leading to disease. Despite their vital role, we have data on just 20% of the potential epigenetic modifiers in humans. I will use novel screen-based technology to find hundreds more, to enable us and others to characterise the role of epigenetics in normal development and disease.