Role of SmcHD1 in X chromosome inactivation.

SmcHD1 在 X 染色体失活中的作用。

• 批准号: nhmrc : 496666
• 负责人: A/Pr Marnie Blewitt
• 金额: $ 32.41万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-smchd1-x-chromosome-inactivation/76902
• 关键词: Role; SmcHD1; chromosome; inactivation.

Epigenetic modifications to the genome do not involve DNA sequence changes but modify gene expression during normal development. In diseases, like cancer, epigenetic modifications modulate gene expression in favour of disease progression. We will study the SmcHD1 gene that is involved in X chromosome inactivation, an epigenetic mechanism operating to ensure equal dosage of X-linked genes between males and females. This project will aid our understanding of chromosome structure and function.

对基因组的表观遗传修饰不涉及DNA序列的改变，而是改变正常发育过程中的基因表达。在癌症等疾病中，表观遗传修饰调节了有利于疾病进展的基因表达。我们将研究与X染色体失活有关的Smchd1基因，这是一种表观遗传机制，旨在确保X连锁基因在男性和女性之间的同等剂量。这个项目将有助于我们对染色体结构和功能的理解。