Role of SmcHD1 in X chromosome inactivation.

基因组的表观遗传修饰不涉及DNA序列的变化，但在正常发育过程中改变基因表达。在疾病中，如癌症，表观遗传修饰调节基因表达，有利于疾病进展。我们将研究SmcHD1基因，该基因参与X染色体失活，这是一种表观遗传机制，可确保男性和女性之间X连锁基因的剂量相等。这个项目将有助于我们了解染色体的结构和功能。

Epigenetic modifications to the genome do not involve DNA sequence changes but modify gene expression during normal development. In diseases, like cancer, epigenetic modifications modulate gene expression in favour of disease progression. We will study the SmcHD1 gene that is involved in X chromosome inactivation, an epigenetic mechanism operating to ensure equal dosage of X-linked genes between males and females. This project will aid our understanding of chromosome structure and function.