Effect of Eythropoietin on Vascular Dysfunction in Human TBI
Effect of Eythropoietin on Vascular Dysfunction in Human TBI
批准号:
7018083
负责人:
CLAUDIA S ROBERTSON
金额:
$26.16万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-03-15 至 2011-01-31
中文摘要
外伤性脑损伤(TBI)引起一系列脑血管功能障碍,从受损
英文摘要
Traumatic brain injury (TBI) induces a spectrum of cerebrovascular dysfunction, ranging from impaired
pressure autoregulation which causes TBI patients to be more vulnerable to secondary ischemic insults to
severe global ischemia. Cerebral blood flow (CBF), especially within the first 12 hr after injury, is strongly
predictive of neurological outcome, with each 10ml/100g/min increase in cortical CBF resulting in a 3-fold
increase in the chances of surviving to hospital discharge. In past studies, a TBI management strategy that
maintained an increased cerebral perfusion pressure to prevent ischemia in patients with severe TBI was
very successful at reducing the incidence of jugular desaturation. However, when this management strategy
was applied to all patients with severe TBI, adverse effects (especially increased incidence of adult
respiratory distress syndrome) appeared to offset any beneficial effect on long-term outcome. Currently, we
are studying the role that testing of dynamic pressure autoregulation might play in identifying those patients
at greatest risk for developing ischemia and who might therefore benefit most from a hypertensive
management strategy. However, we have found that after severe TBI, almost all (87%) patients have
impaired dynamic pressure autoregulation. We now believe that any effective therapy directed at vascular
dysfunction will have to be applied to all patients with severe TBI.
Trauma is the most common cause of death in the 1-44 yr age group, and the third most common cause
for the entire US population. Trauma accounts for more loss of work life-years than cancer and
cardiovascular diseases combined. Effective treatments for this important public health disorder are needed.
Treatment of the cerebrovascular dysfunction caused by TBI could significantly improve neurological
recovery following trauma.
We propose to study the physiological effects of administration of recombinant human erythropoietin
(rhEpo), an agent that has been found to have potent neuroprotective effects after experimental TBI and
spinal cord injury and that has the added benefit of stimulating erythropoiesis in critically ill patients.
Preliminary data suggests that part of the mechanism of neuroprotection by rhEpo is likely to be amelioration
of cerebrovascular dysfunction, possibly through upregulation of endothelial nitric oxide synthase. The goals
of this project include the following: 1. To study the natural history of Epo and Epo receptor expression by
the injured brain; 2. To study the acute effects of rhEpo administration on cerebral hemodynamics; 3. To
study the chronic effects of rhEpo administration on the brain's response to injury.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
31st Annual National Neurotrauma Society(NNS)Symposium
-
批准号:8596881
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
AN ERYTHROPOIETIN-MIMETIC PEPTIDE (pHBSP) FOR TREATMENT OF TBI
-
批准号:8703819
-
项目类别:
-
资助金额:$71.6万
-
财政年份:2013
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
AN ERYTHROPOIETIN-MIMETIC PEPTIDE (pHBSP) FOR TREATMENT OF TBI
-
批准号:8437303
-
项目类别:
-
资助金额:$77.0万
-
财政年份:2013
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Neuroprotection of Erythropoietin Signaling in TBI
-
批准号:7018085
-
项目类别:
-
资助金额:$17.41万
-
财政年份:2005
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Role of NOS3 in the Cerebrovascular Response to TBI
-
批准号:7237924
-
项目类别:
-
资助金额:$29.6万
-
财政年份:2004
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Role of NOS3 in the Cerebrovascular Response to TBI
-
批准号:6948266
-
项目类别:
-
资助金额:$31.22万
-
财政年份:2004
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Role of NOS3 in the Cerebrovascular Response to TBI
-
批准号:7061320
-
项目类别:
-
资助金额:$30.49万
-
财政年份:2004
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Role of NOS3 in the Cerebrovascular Response to TBI
-
批准号:6873344
-
项目类别:
-
资助金额:$31.22万
-
财政年份:2004
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Regulation of Cerebral Blood Flow After Traumatic Brain Injury
-
批准号:6613365
-
项目类别:
-
资助金额:$26.64万
-
财政年份:2002
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Arginine treatment of a reduced cerebral blood flow after traumatic brain injury
-
批准号:6613367
-
项目类别:
-
资助金额:$26.64万
-
财政年份:2002
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Regulation of Cerebral Blood Flow After Traumatic Brain Injury
-
批准号:6470635
-
项目类别:
-
资助金额:$12.12万
-
财政年份:2001
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Regulation of Cerebral Blood Flow After Traumatic Brain Injury
-
批准号:6488272
-
项目类别:
-
资助金额:$26.64万
-
财政年份:2001
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Arginine treatment of a reduced cerebral blood flow after traumatic brain injury
-
批准号:6488274
-
项目类别:
-
资助金额:$26.64万
-
财政年份:2001
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Arginine treatment of a reduced cerebral blood flow after traumatic brain injury
-
批准号:6470637
-
项目类别:
-
资助金额:$12.12万
-
财政年份:2001
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Arginine treatment of a reduced cerebral blood flow after traumatic brain injury
-
批准号:6347679
-
项目类别:
-
资助金额:$12.12万
-
财政年份:2000
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Regulation of Cerebral Blood Flow After Traumatic Brain Injury
-
批准号:6346312
-
项目类别:
-
资助金额:$20.36万
-
财政年份:2000
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Arginine treatment of a reduced cerebral blood flow after traumatic brain injury
-
批准号:6346314
-
项目类别:
-
资助金额:$20.36万
-
财政年份:2000
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Regulation of Cerebral Blood Flow After Traumatic Brain Injury
-
批准号:6347677
-
项目类别:
-
资助金额:$12.12万
-
财政年份:2000
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
Vascular Mechanisms of Secondary Injury After TBI
-
批准号:7204160
-
项目类别:
-
资助金额:$116.73万
-
财政年份:1999
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
VASC MECHS OF SECONDARY INSULTS IN SEVERE BRAIN INJURY
-
批准号:6484283
-
项目类别:
-
资助金额:$5.1万
-
财政年份:1999
-
负责人:CLAUDIA S ROBERTSON
-
依托单位:
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