Analytical & Neuropathology

分析和神经病理学核心提供大体和微观的分析神经化学 病理学，组织，脑脊液和微透析液银行的计划项目。具体目标是：1. 测定硝酸盐/亚硝酸盐作为人和动物脑创伤后一氧化氮代谢的标志物 损伤(TBI)和对促红细胞生成素(EPO)治疗的反应。2.)测量EPO和EPO 人和动物脑外伤后的受体。3.)测定微透析液中炎症的生物标志物 脑损伤后和EPO治疗后的脑脊液样本。4.)为……提供神经病理学支持 实验性颅脑损伤的组织病理学分析，包括挫伤体积的测量，神经元丢失， 和抗原表达。5.)为动物提供组织和脑脊液、血清和微透析液样本库 以及来自TBI的人体组织样本。6.)提供花生四烯酸转化为环氧酶的分析 实验动物脑损伤后的P450产物。与计划项目的前几次迭代一样， 分析和神经病理学核心与主要科学项目和其他 核心。

The Analytical and Neuropathology Core provides analytical neurochemistry, gross and microscopic pathology, and tissue, CSF and microdialysate banking for the Program Project. The Specific Aims are: 1.) measure nitrate/nitrite as markers of nitric oxide metabolism in humans and animals following traumatic brain injury (TBI) and in response to erythropoietin (Epo) administration following TBI. 2.) measure Epo and Epo receptor following TBI in humans and animals. 3.) measure biomarkers of inflammation in microdialysate and CSF samples following TBI and in response to Epo therapy. 4.) provide neuropathology support for histopathological analysis of experimental TBI including measurement of contusion volumes, neuronal loss, and antigen expression. 5.) provide tissue and CSF, serum, and microdialysate sample banking for animal and human tissue samples from TBI. 6.) provide analysis of arachidonic acid conversion to epoxygenase products by P450 following TBI in experimental animals. As in previous iterations of the Program Project, the Analytical and Neuropathology Core interacts closely with the major scientific projects and with the other cores.