Effects of Genetics, Exercise, and Age on Bone Mechanics

遗传、运动和年龄对骨力学的影响

• 批准号: 7261338
• 负责人: Kevin Mallory Middleton
• 金额: $ 1.58万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-09-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7261338
• 关键词: Address; Age; Aging; Architecture; Area; Biology; Bone remodeling; Complex; Computer Simulation; Condition; Data; Decompression Sickness; Diagnosis; Electrons; Engineering; Ensure; Evaluation; Exercise; Fellowship; Femoral Fractures; Femur; Finite Element Analysis; Fracture; Genetic; Growth; Head; Individual; Kinetics; Knowledge; Label; Location; Locomotion; Measures; Mechanical Stress; Mechanics; Modeling; Morphology; Mus; Names; Numbers; Osteon; Osteoporosis; Pattern; Performance; Population; Property; Rate; Reaction; Relative (related person); Research; Role; Running; Scanning; Shapes; Simulate; Skeletal system; Speed; Stress; Stress Fractures; Structural Models; Structure; Techniques; Time; Very Light Exercise; X-Ray Computed Tomography; analytical tool; base; bone; bone strength; in vivo; kinematics; mineralization; nanoindentation; novel strategies; research study; response; sedentary; simulation; three-dimensional modeling

DESCRIPTION (provided by applicant): This project will examine the relative roles of genetic background, exercise, and aging on bone performance, using two new approaches. First, mice, which are of known genetic background and which have been selected for high levels of voluntary exercise, will be raised with and without access to a running wheel. This will allow genetic and exercise effects on skeletal function to be statistically separated from one another. Second, a comprehensive bone analysis approach will be used, in which the entire proximal femur will be studied, from microscale material properties to gross bone morphology. Nanoindentation and micro-computed tomography will allow highly accurate finite element analysis of the mouse femora. Additional aims of this project include the determination of mineralization and remodeling patterns in response to exercise, the identification of areas of high stress in the femur during locomotion, and evaluation of models of fracture mechanics. In addition to the fundamental questions of bone biology addressed in this project, the results will permit a better understanding of the relationship between genetics, exercise, and aging, which will have significant implications for the prediction and diagnosis of osteoporosis.

描述（由申请人提供）：本项目将使用两种新方法研究遗传背景、运动和衰老对骨性能的相对作用。首先，具有已知遗传背景并被选择进行高水平自愿运动的小鼠将在有和没有跑步轮的情况下饲养。这将使遗传和运动对骨骼功能的影响在统计上相互分离。其次，将使用全面的骨分析方法，其中将研究整个股骨近端，从微观材料特性到大体骨形态。纳米压痕和微型计算机断层扫描将允许高度精确的有限元分析的小鼠股骨。该项目的其他目的包括确定运动时的矿化和重塑模式，确定运动过程中股骨的高应力区域，以及评估骨折力学模型。除了在这个项目中解决的骨生物学的基本问题，结果将允许更好地了解遗传学，运动和衰老之间的关系，这将对骨质疏松症的预测和诊断具有重要意义。

项目成果

Functional significance of genetic variation underlying limb bone diaphyseal structure.

四肢骨干结构遗传变异的功能意义。

• DOI: 10.1002/ajpa.21286
• 发表时间: 2010
• 期刊: American journal of physical anthropology
• 影响因子: 2.8
• 作者: Wallace,IanJ;Middleton,KevinM;Lublinsky,Svetlana;Kelly,ScottA;Judex,Stefan;GarlandJr,Theodore;Demes,Brigitte
• 通讯作者: Demes,Brigitte

Variation in within-bone stiffness measured by nanoindentation in mice bred for high levels of voluntary wheel running.

通过纳米压痕测量高水平自愿轮跑饲养小鼠的骨内硬度变化。

• DOI: 10.1111/j.1469-7580.2009.01175.x
• 发表时间: 2010
• 期刊: Journal of anatomy
• 影响因子: 2.4
• 作者: Middleton,KevinM;Goldstein,BethD;Guduru,PradeepR;Waters,JulieF;Kelly,ScottA;Swartz,SharonM;GarlandJr,T
• 通讯作者: GarlandJr,T

The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics in aged mice: evidence from an artificial selection experiment.

遗传学和表型可塑性在决定老年小鼠骨形态和力学方面的相对重要性：来自人工选择实验的证据。

• DOI: 10.1016/j.zool.2007.06.003
• 发表时间: 2008
• 期刊: Zoology (Jena, Germany)
• 作者: Middleton,KevinM;Shubin,CorinneE;Moore,DouglasC;Carter,PatrickA;GarlandJr,Theodore;Swartz,SharonM
• 通讯作者: Swartz,SharonM

Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice.

选择性育种作为探测小鼠骨骼对高自主运动活动反应的工具。

• DOI: 10.1093/icb/icn057
• 发表时间: 2008
• 期刊: Integrative and comparative biology
• 影响因子: 2.6
• 作者: Middleton,KevinM;Kelly,ScottA;GarlandJr,Theodore
• 通讯作者: GarlandJr,Theodore