Effects of Genetics, Exercise, and Age on Bone Mechanics

遗传、运动和年龄对骨力学的影响

• 批准号: 6999002
• 负责人: Kevin Mallory Middleton
• 金额: $ 4.83万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999002
• 关键词: aging; biomarker; biomechanics; bone fracture; bone imaging /visualization /scanning; bone metabolism; computed axial tomography; exercise; femur; gene environment interaction; genetic strain; laboratory mouse; osteoporosis; postdoctoral investigator; skeletal stress

DESCRIPTION (provided by applicant): This project will examine the relative roles of genetic background, exercise, and aging on bone performance, using two new approaches. First, mice, which are of known genetic background and which have been selected for high levels of voluntary exercise, will be raised with and without access to a running wheel. This will allow genetic and exercise effects on skeletal function to be statistically separated from one another. Second, a comprehensive bone analysis approach will be used, in which the entire proximal femur will be studied, from microscale material properties to gross bone morphology. Nanoindentation and micro-computed tomography will allow highly accurate finite element analysis of the mouse femora. Additional aims of this project include the determination of mineralization and remodeling patterns in response to exercise, the identification of areas of high stress in the femur during locomotion, and evaluation of models of fracture mechanics. In addition to the fundamental questions of bone biology addressed in this project, the results will permit a better understanding of the relationship between genetics, exercise, and aging, which will have significant implications for the prediction and diagnosis of osteoporosis.

描述（由申请人提供）：该项目将使用两种新方法研究遗传背景、运动和衰老对骨骼性能的相对作用。首先，具有已知遗传背景并经过选择进行高水平自愿运动的小鼠将在有或没有跑轮的情况下饲养。这将使遗传和运动对骨骼功能的影响在统计上相互分离。其次，将使用全面的骨骼分析方法，对整个股骨近端进行研究，从微观材料特性到大体骨形态。纳米压痕和微型计算机断层扫描将允许对小鼠股骨进行高精度的有限元分析。该项目的其他目标包括确定运动响应的矿化和重塑模式、识别运动过程中股骨的高应力区域以及评估断裂力学模型。除了该项目解决的骨生物学基本问题外，研究结果还将有助于更好地理解遗传学、运动和衰老之间的关系，这将对骨质疏松症的预测和诊断产生重大影响。