以患者为中心的临床营养研究-猫眼课题宝

以患者为中心的临床营养研究

批准号：

7185258

负责人：

Thomas R Ziegler

金额：

$16.12万

依托单位：

EMORY UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-07-01 至 2012-06-30

来源：

https://reporter.nih.gov/project-details/7185258

关键词：

3-nitrotyrosine Abdomen Academic Medical Centers Acetaminophen Acute Adipose tissue Adult Advisory Committees Affect Alabama Alberta province Allogeneic Bone Marrow Transplantation American American Medical Association Amino Acids Anabolic Agents Animal Experiments Animal Model Animals Apoptosis Appendix Applications Grants Area Arts Attenuated Autologous Bone Marrow Transplantation Award Awareness Bacterial Toxins Basic Science Belief Biochemistry Biography Biological Assay Biological Markers Biopsy Biopsy Specimen Biotechnology Blood Blood Vessels Blood specimen Body Weight decreased Bone Marrow Transplantation Book Chapters Boston Burn Trauma Burn injury C-reactive protein Caco-2 Cells Canada Cardiac Caring Cell Line Cell Proliferation Cell model Cell physiology Cells Centers for Disease Control and Prevention (U.S.)Chairperson Chemicals Child Child health care Childhood China Chronic Chronic Kidney Failure Class Clinic Clinical Clinical Endocrinology Clinical Investigator Clinical Investigator Award Clinical Nutrition Clinical Research Clinical Trials Clinical and Translational Science Awards Clinical assessments Cobalamin Collaborations Commit Committee Members Communicable Diseases Communities Complex Consult Continuing Education Controlled Clinical Trials Coupled Critical Care Critical Illness Critiques Cultured Cells Cysteine Cystic Fibrosis Cystine Cytoprotection Daily Dana-Farber Cancer Institute Data Dedications Development Diabetes Mellitus Diarrhea Diet Diet Research Dietary Proteins Dietary Sulfur Dietary Supplementation Dietary intake Digestive System Disorders Dipeptides Discipline Disease Doctor of Medicine Doctor of Philosophy Dose Double-Blind Method Down-Regulation EGF gene Education Educational Curriculum Educational process of instructing End Point Endocrinology Engraftment Enrollment Enteral Enteral Nutrition Environment Epidemic Epithelial Epithelial Cells Epithelium Equilibrium Equipment Excision Exhibits Exposure to Extracellular Fluid Faculty Failure Fellowship Female Flagellin Food deprivation (experimental)Fostering Foundations Functional disorder Fund Raising Funding Funding Opportunities Future GAG Gene GLP-2 Gastric Bypass Gastroenterologist Gastroenterology Gene Proteins Gene Targeting General Hospitals Generations Genes Germany Glucose Glutamine Glutathione Goals Grant Growth Growth Factor Growth Factor Interaction HT29 Cells Health Health Sciences Hematology Hemodialysis Hormones Hospital Costs Hospital Mortality Hospitals House Staffs Human Human Resources Hypersensitivity Immune Immune response Immunity Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins In Vitro Incidence Income Individual Industry Infant Infection Inflammation Inflammatory Inflammatory Bowel Diseases Institute of Medicine (U.S.)Institutes Institution Insulin Insulin Resistance Insulin-Like Growth Factor I Intake Intensive Care Units Interdisciplinary Study Interleukin-6 Internal Medicine Internist Internships Intervention Intestinal Absorption Intestines Intravenous Investigation Iowa Isoprostanes Israel Italy Japan Joints Journals Junior Physician Kidney Kidney Failure Laboratories Laboratory Technicians Lead Leadership Learning Left Legal patent Length of Stay Letters Light Link Lipids Lipopolysaccharides Liquid substance Literature Lobbying Lung Macronutrients Nutrition Malignant Neoplasms Malnutrition Manuscripts Master of Public Health Master of Science Measurement Measures Mechanical ventilation Medial Mediating Mediator of activation protein Medical Medical Education Medical Students Medical center Medicine Mediterranean Diet Mentored Clinical Scientist Development Program Mentors Mentorship Messenger RNA Metabolic Metabolic syndrome Metabolism Metalloproteases Methodology Methods Mexican Michigan Microbiology Micronutrients Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Minority Mission Modality Modeling Molecular Molecular Biology Moods Morbidity - disease rate Motor Mucous Membrane Multicenter Studies NCI Scholars Program Names National Center for Research Resources National Institute of Diabetes and Digestive and Kidney Diseases National Research Service Awards Neurology Nigeria Nomads North Carolina Nosocomial Infections Numbers Nurses Nutrient Nutritional Nutritional Study Nutritional Support Nutritionist Obesity Ohio Operative Surgical Procedures Oral Osteopathic Medicine Outcome Oxandrolone Oxidation-Reduction Oxidative Stress Paper Parenteral Nutrition Parkinson Disease Pathway interactions Patients Pediatric Neurology Pediatrics Peer Review PepT1 protein Peptides Performance Pharmacists Pharmacology Phase Phase II Clinical Trials Physicians Pilot Projects Placebo Control Plasma Play Population Positioning Attribute Postdoctoral Fellow Preparation Prevention Preventive Primates Principal Investigator Problem-Based Learning Program Research Project Grants Protein Chemistry Protein-Energy Malnutrition Proteins Proteomics Protocols documentation Psychiatry Public Health Schools Publications Publishing Publishing Peer Reviews Pyrimidine Pyrimidines Quality of life Randomized Randomized Controlled Clinical Trials Randomized Controlled Trials Rate Rattus Reading Receptor Signaling Recombinant Growth Factor Recombinant Growth Hormone Recombinants Recommendation Recording of previous events Recruitment Activity Regulation Rehabilitation therapy Rehydrations Relative (related person)Reporting Research Research Design Research Personnel Research Project Grants Research Training Residencies Residual state Resistance Resolution Resources Role Rotation Rural SECTM1 gene Safety Sampling Satiation Schools Science Scientist Score Sepsis Series Serum Services Short Bowel Syndrome Sickle Cell Anemia Site Skeletal Muscle Skeleton Small Intestines Societies Somatomedins Somatotropin Source Spain Specialist Staging Standards of Weights and Measures Staphylococcus aureus Stomach Stress Students Study Subject Sulfur Sulfur Amino Acids Supplementation Support of Research Surgeon Symptoms Syndrome System T-Lymphocyte Techniques Technology Tern Testing Thalassemia Therapeutic Agents Thioredoxin Time Tissues Title Tokyo Total Parenteral Nutrition Toxic effect Training Training Programs Transgenic Animals Translating Translational Research Transplantation Trefoil USA Georgia United States United States Food and Drug Administration United States National Institutes of Health Universities University Hospitals Up-Regulation Uracil Variant Visceral Vitamin D Weaning Week Weight Western Asia Georgia Woman Work Writing Zinc Zinc deficiency absorption abstracting bacterial resistance base career cell growth clinical effect clinical efficacy college comparative concept conditionally essential amino acid cytokine day design dietary supplements editorial experience extracellular farm worker fascinate food science ghrelin hospital laboratories improved in vivo indexing instructor insulin sensitivity interest keratinocyte growth factor lectures lipid metabolism liver transplantation man medical schools member metabolic abnormality assessment metabolomics microbial colonization mortality multidisciplinary nitrogen balance novel nutrition nutrition education oncology oral mucositis orotate oxidation patient oriented research pediatric department pilot trial pre-clinical prevent professor programs prospective protein expression r-hGH-M ranpirnase repaired research and development research study response role model sickling size skills success symposium tool translational study tube feeding

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中文摘要

翻译

描述(由申请者提供)：本申请为以患者为中心的研究的职业生涯中期奖(K24)寻求支持医生营养专家和临床和转化性营养科学的公认的研究人员。P.I.致力于开展以患者为中心的研究(POR)，专注于营养，并指导临床住院医生、研究员和临床营养研究的初级教员，以培养一支新的临床营养研究队伍。这项提议将提供受保护的时间，使私人侦探能够推进他在营养导向研究方面的研究和指导工作，并提供额外的培训和资源，这反过来将增强他在营养相关研究中指导医生和其他临床研究人员的能力。申请者在营养和医学方面有独特的培训背景，并在联邦、基金会和行业为他的研究人员发起的POR和翻译研究提供资金方面有着出色的记录。他有良好的出版记录和在国家营养相关协会担任领导职务的历史，并在一线营养杂志的编辑委员会服务。在Emory，P.I.担任NIH资助的GCRC、K12 Emory临床研究导师(EMCRS)和K30临床研究硕士(MSCR)项目、临床和分子营养中心以及营养与健康科学研究生项目的领导--所有这些都为POR提供了指导机会。P.I.已经指导了18名学员，其中包括目前由内科、外科、神经学和儿科的5名内科初级教员组成的干部，2名博士生初级教员临床研究员，以及3名同时进行临床和转化性营养研究的博士生。候选人的研究计划包括基于GCRC的关于谷氨酰胺在分解代谢状态(包括重症监护和镰状细胞性贫血)的有效性和机制的研究，关于短肠综合征和内科/外科减肥后代谢适应的研究，以及与饮食相关的氧化还原控制研究。本K24课程的具体目标是：1)提供受保护的时间，使私人投资者能够在POR的现有和新学员中增加他的指导活动；2)促进私人投资者S在其当前临床研究的背景下发展营养代谢组学和新的氧化还原相关措施的新研究技能，使他能够培训受训者这些新措施；以及3)促进申请人的职业发展。

英文摘要

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient Oriented Research (K24) seeks support for a physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. is committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring clinical residents, fellows and junior faculty in clinical nutrition research to develop a new cadre of investigators in Clinical Nutrition. This proposal will provide protected time to enable the P.I. to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He has a strong publication record and a history of leadership roles in national nutrition-related societies and service on editorial boards of front-line nutrition journals. At Emory, the P.I. serves in the leadership of the NIH-funded GCRC, K12 Emory Mentored Clinical Research Scholars (EMCRS) and K30 Masters of Science in Clinical Research (MSCR) programs, the Center for Clinical and Molecular Nutrition and the graduate program in Nutrition and Health Science - all of which provide opportunities for mentoring in POR. The P.I. has mentored more than 18 trainees, including a current cadre of 5 physician junior faculty members in Medicine, Surgery, Neurology and Pediatrics, 2 Ph.D. junior faculty clinical investigators, and 3 Ph.D. students who conduct both clinical and translational nutrition research. The candidate's research program includes GCRC-based studies on the efficacy and mechanisms of glutamine in catabolic states, including critical care and sickle cell anemia, on metabolic adaptation in short bowel syndrome and after medical/surgical weight loss, and studies on diet-related redox control. The specific aims of this K24 are: 1) to provide protected time enabling the P.I. to increase his mentoring activities among current and new trainees in POR; 2) to facilitate the P.I.'s development of new research skills in nutritional metabolomics and new redox-related measures within the context of his current clinical research, enabling him to train mentees in these new measures; and 3) to faciliate the career development of the applicant.

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