Patient Oriented Research in Clinical Nutrition

以患者为中心的临床营养研究

• 批准号: 7667313
• 负责人: Thomas R Ziegler
• 金额: $ 16.77万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7667313
• 关键词: Applications Grants; Body Weight decreased; Clinical; Clinical Investigator; Clinical Nutrition; Clinical Research; Commit; Critical Care; Development; Diet; Doctor of Philosophy; Faculty; Fellowship; Foundations; Funding; Glutamine; Health Sciences; Hospitals; Industry; Journals; Junior Physician; Leadership; Master of Science; Measures; Medical; Medicine; Mentors; Metabolic; Midcareer Investigator Award in Patient-Oriented Research; Molecular; Nutritional; Nutritional Study; Operative Surgical Procedures; Oxidation-Reduction; Pediatric Neurology; Peer Review; Physicians; Publications; Recording of previous events; Research; Research Personnel; Resources; Role; SECTM1 gene; Science; Services; Short Bowel Syndrome; Sickle Cell Anemia; Societies; Specialist; Students; Time; Training; Translational Research; base; career development; editorial; member; metabolomics; nutrition; patient oriented research; professor; programs; skills

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient Oriented Research (K24) seeks support for a physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. is committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring clinical residents, fellows and junior faculty in clinical nutrition research to develop a new cadre of investigators in Clinical Nutrition. This proposal will provide protected time to enable the P.I. to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He has a strong publication record and a history of leadership roles in national nutrition-related societies and service on editorial boards of front-line nutrition journals. At Emory, the P.I. serves in the leadership of the NIH-funded GCRC, K12 Emory Mentored Clinical Research Scholars (EMCRS) and K30 Masters of Science in Clinical Research (MSCR) programs, the Center for Clinical and Molecular Nutrition and the graduate program in Nutrition and Health Science - all of which provide opportunities for mentoring in POR. The P.I. has mentored more than 18 trainees, including a current cadre of 5 physician junior faculty members in Medicine, Surgery, Neurology and Pediatrics, 2 Ph.D. junior faculty clinical investigators, and 3 Ph.D. students who conduct both clinical and translational nutrition research. The candidate's research program includes GCRC-based studies on the efficacy and mechanisms of glutamine in catabolic states, including critical care and sickle cell anemia, on metabolic adaptation in short bowel syndrome and after medical/surgical weight loss, and studies on diet-related redox control. The specific aims of this K24 are: 1) to provide protected time enabling the P.I. to increase his mentoring activities among current and new trainees in POR; 2) to facilitate the P.I.'s development of new research skills in nutritional metabolomics and new redox-related measures within the context of his current clinical research, enabling him to train mentees in these new measures; and 3) to faciliate the career development of the applicant.

描述(由申请者提供)：本申请为以患者为中心的研究的职业生涯中期奖(K24)寻求支持医生营养专家和临床和转化性营养科学的公认的研究人员。P.I.致力于开展以患者为中心的研究(POR)，专注于营养，并指导临床住院医生、研究员和临床营养研究的初级教员，以培养一支新的临床营养研究队伍。这项提议将提供受保护的时间，使私人侦探能够推进他在营养导向研究方面的研究和指导工作，并提供额外的培训和资源，这反过来将增强他在营养相关研究中指导医生和其他临床研究人员的能力。申请者在营养和医学方面有独特的培训背景，并在联邦、基金会和行业为他的研究人员发起的POR和翻译研究提供资金方面有着出色的记录。他有良好的出版记录和在国家营养相关协会担任领导职务的历史，并在一线营养杂志的编辑委员会服务。在Emory，P.I.担任NIH资助的GCRC、K12 Emory临床研究导师(EMCRS)和K30临床研究硕士(MSCR)项目、临床和分子营养中心以及营养与健康科学研究生项目的领导--所有这些都为POR提供了指导机会。P.I.已经指导了18名学员，其中包括目前由内科、外科、神经学和儿科的5名内科初级教员组成的干部，2名博士生初级教员临床研究员，以及3名同时进行临床和转化性营养研究的博士生。候选人的研究计划包括基于GCRC的关于谷氨酰胺在分解代谢状态(包括重症监护和镰状细胞性贫血)的有效性和机制的研究，关于短肠综合征和内科/外科减肥后代谢适应的研究，以及与饮食相关的氧化还原控制研究。本K24课程的具体目标是：1)提供受保护的时间，使私人投资者能够在POR的现有和新学员中增加他的指导活动；2)促进私人投资者S在其当前临床研究的背景下发展营养代谢组学和新的氧化还原相关措施的新研究技能，使他能够培训受训者这些新措施；以及3)促进申请人的职业发展。