Patient Oriented Research in Clinical Nutrition

描述（由申请人提供）：本申请以患者为导向的研究（K24）中的职业生涯中期研究员奖寻求对临床和转化营养科学领域的医师营养专家和知名研究员的支持。 P.I.致力于开展以患者为中心的研究（POR），重点关注营养，并指导临床营养研究的临床住院医生、研究员和初级教员，以培养临床营养领域的新研究人员骨干。该提案将为 P.I. 提供受保护的时间。推进他在营养导向研究方面的研究和指导工作，并提供额外的培训和资源，从而增强他在营养相关研究中指导医生和其他临床研究人员的能力。申请人在营养和医学方面拥有独特的培训背景，并且在联邦、基金会和行业资助其研究者发起的 POR 和转化研究方面拥有良好的记录。他拥有良好的发表记录，并在国家营养相关学会中担任领导职务，并在一线营养期刊的编辑委员会任职。在埃默里大学，P.I.领导 NIH 资助的 GCRC、K12 埃默里指导临床研究学者 (EMCRS) 和 K30 临床研究理学硕士 (MSCR) 项目、临床和分子营养中心以及营养与健康科学研究生项目 - 所有这些都为 POR 提供指导机会。 P.I.已指导超过 18 名学员，其中包括 5 名医学、外科、神经病学和儿科领域的初级医师骨干，2 名博士。初级临床研究人员和 3 名博士。进行临床和转化营养研究的学生。该候选人的研究项目包括基于 GCRC 的谷氨酰胺在分解代谢状态下的功效和机制的研究，包括重症监护和镰状细胞性贫血、短肠综合征和药物/手术减肥后的代谢适应，以及与饮食相关的氧化还原控制的研究。 K24 的具体目标是：1) 提供受保护的时间，使 P.I.加强对 POR 现有学员和新学员的指导活动； 2) 促进 P.I. 在其当前临床研究的背景下发展营养代谢组学和新的氧化还原相关措施方面的新研究技能，使他能够对学员进行这些新措施的培训； 3) 促进申请人的职业发展。

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient Oriented Research (K24) seeks support for a physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. is committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring clinical residents, fellows and junior faculty in clinical nutrition research to develop a new cadre of investigators in Clinical Nutrition. This proposal will provide protected time to enable the P.I. to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He has a strong publication record and a history of leadership roles in national nutrition-related societies and service on editorial boards of front-line nutrition journals. At Emory, the P.I. serves in the leadership of the NIH-funded GCRC, K12 Emory Mentored Clinical Research Scholars (EMCRS) and K30 Masters of Science in Clinical Research (MSCR) programs, the Center for Clinical and Molecular Nutrition and the graduate program in Nutrition and Health Science - all of which provide opportunities for mentoring in POR. The P.I. has mentored more than 18 trainees, including a current cadre of 5 physician junior faculty members in Medicine, Surgery, Neurology and Pediatrics, 2 Ph.D. junior faculty clinical investigators, and 3 Ph.D. students who conduct both clinical and translational nutrition research. The candidate's research program includes GCRC-based studies on the efficacy and mechanisms of glutamine in catabolic states, including critical care and sickle cell anemia, on metabolic adaptation in short bowel syndrome and after medical/surgical weight loss, and studies on diet-related redox control. The specific aims of this K24 are: 1) to provide protected time enabling the P.I. to increase his mentoring activities among current and new trainees in POR; 2) to facilitate the P.I.'s development of new research skills in nutritional metabolomics and new redox-related measures within the context of his current clinical research, enabling him to train mentees in these new measures; and 3) to faciliate the career development of the applicant.