Patient Oriented Research in Clinical Nutrition

描述（由申请人提供）：本申请为中期职业研究者奖在以患者为导向的研究（K24）寻求支持的医生营养专家和建立研究者在临床和转化营养科学。私家侦探致力于执行以病人为导向的研究（POR），重点是营养，并在指导临床住院医师，研究员和初级教师在临床营养研究，以发展一个新的干部队伍的研究人员在临床营养。该提案将提供受保护的时间，使P.I.推进他在营养导向研究方面的研究和指导工作，并提供额外的培训和资源，从而提高他在营养相关研究中指导医生和其他临床研究人员的能力。申请人在营养和医学方面具有独特的培训背景，并在联邦，基金会和行业资助方面有着良好的记录，用于他的制药商发起的POR和转化研究。他有很好的出版记录，在国家营养相关协会担任领导职务，并在一线营养期刊的编辑委员会任职。在埃默里，私家侦探。担任领导NIH资助的GCRC，K12埃默里指导临床研究学者（EMCRS）和K30临床研究硕士（MSCR）计划，临床和分子营养中心以及营养与健康科学研究生课程-所有这些都为POR提供指导机会。私家侦探已经指导了超过18名学员，其中包括5名内科、外科、神经病学和儿科的初级医师，2名博士。初级教师临床研究员和3名博士从事临床和转化营养研究的学生。候选人的研究计划包括基于GCRC的研究，研究谷氨酰胺在分解代谢状态下的疗效和机制，包括重症监护和镰状细胞性贫血，在短肠综合征和医疗/手术减肥后的代谢适应，以及饮食相关的氧化还原控制研究。这个K24的具体目标是：1）提供保护时间，使P. I。增加他在POR现有和新学员中的指导活动; 2）促进P.I.在他目前的临床研究背景下，发展营养代谢组学和新的氧化还原相关措施的新研究技能，使他能够在这些新措施方面培训学员;以及3）促进申请人的职业发展。

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient Oriented Research (K24) seeks support for a physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. is committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring clinical residents, fellows and junior faculty in clinical nutrition research to develop a new cadre of investigators in Clinical Nutrition. This proposal will provide protected time to enable the P.I. to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He has a strong publication record and a history of leadership roles in national nutrition-related societies and service on editorial boards of front-line nutrition journals. At Emory, the P.I. serves in the leadership of the NIH-funded GCRC, K12 Emory Mentored Clinical Research Scholars (EMCRS) and K30 Masters of Science in Clinical Research (MSCR) programs, the Center for Clinical and Molecular Nutrition and the graduate program in Nutrition and Health Science - all of which provide opportunities for mentoring in POR. The P.I. has mentored more than 18 trainees, including a current cadre of 5 physician junior faculty members in Medicine, Surgery, Neurology and Pediatrics, 2 Ph.D. junior faculty clinical investigators, and 3 Ph.D. students who conduct both clinical and translational nutrition research. The candidate's research program includes GCRC-based studies on the efficacy and mechanisms of glutamine in catabolic states, including critical care and sickle cell anemia, on metabolic adaptation in short bowel syndrome and after medical/surgical weight loss, and studies on diet-related redox control. The specific aims of this K24 are: 1) to provide protected time enabling the P.I. to increase his mentoring activities among current and new trainees in POR; 2) to facilitate the P.I.'s development of new research skills in nutritional metabolomics and new redox-related measures within the context of his current clinical research, enabling him to train mentees in these new measures; and 3) to faciliate the career development of the applicant.