MECHANISMS OF ADAPTATION IN HUMAN SHORT BOWEL SYNDROME

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to determine after massive SBR whether the residual small bowel and colonic mucosa exhibits adaptive growth, with concomitantly improved nutrient absorption and gut barrier function. In addition, the study aims to determine potential mechanisms of early gut adaptation in human SBS by evaluating changes in mucosal cell proliferation and apoptosis and expression of key molecules known to regulate nutrient transport/absorption and gut barrier function and to evaluate the utility of plasma citrulline concentrations and serum flagellin antibody titers as biomarkers for human enterocyte absorptive capacity and gut barrier function, respectively.