EFFICACY AND MECHANISMS OF GLN DPEPTIDE IN THE SICU

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在确定AG-PN是否降低SICU患者的住院死亡率、医院感染和其他医院发病率指数；确定AG-PN是否改善肠道屏障功能指数；确定AG-PN是否改善先天免疫和获得性免疫指数；以及确定AG-PN是否增加全身细胞保护分子的浓度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to determine whether AG-PN decreases hospital mortality, nosocomial infections, and other indices of hospital morbidity in SICU patients; to determine whether AG-PN improves indices of gut barrier function; to determine whether AG-PN improves indices of innate and adaptive immunity; and to determine whether AG-PN increases systemic concentrations of cytoprotective molecules.