Patient Oriented Research In Clinical Nutrition

以患者为中心的临床营养研究

• 批准号: 9103104
• 负责人: Thomas R Ziegler
• 金额: $ 17.75万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-16 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9103104
• 关键词: Area; Bioinformatics; Clinical; Clinical Investigator; Clinical Nutrition; Clinical Research; Clinical Sciences; Critical Care; Critical Illness; Cystic Fibrosis; Development; Diet; Dietary Intervention; Discipline; Discipline of Nursing; Doctor of Philosophy; Dose; Faculty; Female; Foundations; Funding; Funding Applicant; Generations; Glutamine; Goals; Grant; Health Sciences; Industry; Institutes; International; Journals; Junior Physician; Leadership; Link; Medical; Medical Students; Medicine; Mentors; Metabolic; Metabolism; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Minority Groups; Molecular; Nutrition Assessment; Nutritional; Nutritional Science; Nutritional Study; Operative Surgical Procedures; Oxidation-Reduction; Patients; Pediatrics; Physicians; Plasma; Postdoctoral Fellow; Productivity; Publications; Pulmonary Tuberculosis; Recording of previous events; Research; Research Activity; Research Design; Research Institute; Research Personnel; Research Training; Resources; Role; Sampling; Services; Short Bowel Syndrome; Sickle Cell Anemia; Societies; Source; Specialist; Study Section; TNFSF15 gene; Therapeutic; Time; Training; Training and Education; Translational Research; United States National Institutes of Health; Vitamin D; Wages; Western Asia Georgia; biomarker discovery; career development; editorial; education research; ethnic minority population; global health; graduate student; innovation; investigator training; member; metabolomics; multidisciplinary; novel; nutrition; outcome prediction; patient oriented; patient oriented research; patient population; post-doctoral training; pre-doctoral; programs; senior faculty; skills; tool; undergraduate student

DESCRIPTION (provided by applicant): This competing renewal application for the Midcareer Investigator Award in Patient Oriented Research (K24) "Patient-Oriented Research in Clinical Nutrition" seeks support for an accomplished physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. remains highly committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring undergraduates, graduate and medical students, postdoctoral fellows, clinical residents, and junior faculty in clinical nutrition research to continue to develop a needed new cadre of well-trained investigators in Clinical Nutrition. Renewal of this proposal will provide protected time t enable the P.I. to continue to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources in state-of-the-art metabolomics methods that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He maintains a strong and growing publication record, renewed independent funding for POR from NIH and other sources, a continued history of leadership roles in national nutrition- related societies, and increasing service on the editorial boards of front-line nutrition-oriented research journals. At Emory, the P.I. serves in the leadership of the NIH-funded CTSA grant, the Atlanta Clinical and Translational Science Institute (ACTSI), including as Co-Program Director of the ACTSI Research Education, Training and Career Development (RETCD) program, Co-Program Director of the ACTSI/RETCD KL2 postdoctoral training grant, and Program Director of the ACTSI/RETCD TL1 predoctoral training grant (TL1 RR025010). He serves in leadership roles with the Center for Clinical and Molecular Nutrition, several T32 training grants and the Emory graduate program in Nutrition and Health Science - all of which provide opportunities for continued mentoring in POR. Since the initial funding of this K24 grant (07/01/07), the P.I. has mentored the clinical/translational research activities of 32 trainees, from the level of undergraduate student to junior faculty, including a current cadre of 3 physician junior faculty members from the Emory Departments of Medicine and Pediatrics, respectively; 2 Ph.D. junior faculty investigators; 4 international physician investigators from the former Soviet Republic of Georgia; 3 physician postdoctoral fellows; 4 Ph.D.-trained postdoctoral fellows; a Pharm.D. specialist in clinical nutrition support; 3 Emory Ph.D. graduate students (2 in Nutrition and Health Sciences and 1 in Nursing) and an Emory undergraduate student. The candidate's POR program provides a rich training substrate for current and potential mentees and includes ACTSI-leveraged studies on the efficacy and metabolic impact of glutamine in catabolic states, including critical care, short bowel syndrome, cystic fibrosis. sickle cell anemia, diet-related redox control and metabolomics analysis.

描述（由申请人提供）：这项竞争性的职业中期研究者奖更新申请在以患者为导向的研究（K24）“以患者为导向的临床营养研究”寻求支持一个有成就的医生营养专家和建立临床和转化营养科学研究。私家侦探仍然高度致力于执行以病人为导向的研究（POR），重点是营养，并在指导本科生，研究生和医学生，博士后研究员，临床住院医生，和初级教师在临床营养研究，继续发展所需的训练有素的研究人员在临床营养的新干部。更新本提案将提供受保护的时间，使P.I.继续推进他在营养导向研究方面的研究和指导工作，并在最先进的代谢组学方法方面提供额外的培训和资源，这将反过来提高他指导医生和其他临床研究人员的能力 与营养相关的研究。申请人在营养和医学方面具有独特的培训背景，并在联邦，基金会和行业资助方面有着良好的记录，用于他的制药商发起的POR和转化研究。他保持着强劲且不断增长的出版记录，从NIH和其他来源为POR提供了新的独立资金，在国家营养相关协会中继续担任领导角色，并增加了对前线营养导向研究期刊编辑委员会的服务。在埃默里，私家侦探。担任NIH资助的CTSA补助金，亚特兰大临床和转化科学研究所（ACTSI）的领导，包括ACTSI研究教育，培训和职业发展（RETCD）计划的联合项目主任，ACTSI/RETCD KL 2博士后培训补助金的联合项目主任，以及ACTSI/RETCD TL 1博士前培训补助金（TL 1 RR 025010）的项目主任。他在临床和分子营养中心担任领导职务，几个T32培训赠款和埃默里营养与健康科学研究生课程-所有这些都为POR提供了继续指导的机会。自K24赠款的初始供资（07/01/07）以来，P.I.指导了32名学员的临床/转化研究活动，从本科生到初级教师，包括目前分别来自埃默里医学和儿科系的3名医生初级教师; 2名博士。初级教员调查员; 4名来自前苏联格鲁吉亚共和国的国际医师研究员; 3名医师博士后研究员; 4名博士-受过训练的博士后研究员;临床营养支持专家; 3埃默里博士研究生（2名营养与健康科学专业，1名护理专业）和一名埃默里大学本科生。候选人的POR计划为当前和潜在的学员提供了丰富的培训基础，包括ACTSI利用谷氨酰胺在分解代谢状态下的疗效和代谢影响的研究，包括重症监护，短肠综合征，囊性纤维化。镰状细胞性贫血、饮食相关的氧化还原控制和代谢组学分析。

项目成果

Ethanol Lock Therapy Markedly Reduces Catheter-Related Blood Stream Infections in Adults Requiring Home Parenteral Nutrition: A Retrospective Study From a Tertiary Medical Center.

乙醇封管疗法可显着减少需要家庭肠外营养的成人的导管相关血流感染：来自三级医疗中心的回顾性研究。

• DOI: 10.1002/jpen.1698
• 发表时间: 2020
• 期刊: JPEN. Journal of parenteral and enteral nutrition
• 作者: Gundogan,Kursat;Dave,NishaJ;Griffith,DanielP;Zhao,VivianM;McNally,ThereseA;Easley,KirkA;Haack,CarlaI;Galloway,JohnR;Ziegler,ThomasR
• 通讯作者: Ziegler,ThomasR

Outcomes of percutaneous endoscopic gastrostomy in hospitalized patients at a tertiary care center in Turkey.

• DOI: 10.1038/ejcn.2014.11
• 发表时间: 2014-04
• 期刊: European journal of clinical nutrition
• 影响因子: 4.7

Use of Reticulocyte Hemoglobin Content in the Assessment of Iron Deficiency in Children With Inflammatory Bowel Disease.

• DOI: 10.1097/mpg.0000000000001335
• 发表时间: 2017-05
• 期刊: Journal of pediatric gastroenterology and nutrition
• 影响因子: 2.9
• 作者: Syed S;Kugathasan S;Kumar A;Prince J;Schoen BT;McCracken C;Ziegler TR;Suchdev PS
• 通讯作者: Suchdev PS

Determinants of Anemia among School-Aged Children in Mexico, the United States and Colombia.

• DOI: 10.3390/nu8070387
• 发表时间: 2016-06-23
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Syed S;Addo OY;De la Cruz-Góngora V;Ashour FA;Ziegler TR;Suchdev PS
• 通讯作者: Suchdev PS

Amino Acid Concentrations in HIV-Infected Youth Compared to Healthy Controls and Associations with CD4 Counts and Inflammation.

• DOI: 10.1089/aid.2015.0369
• 发表时间: 2017-07
• 期刊: AIDS research and human retroviruses
• 影响因子: 1.5
• 作者: T. Ziegler;S. Judd;Joshua H. Ruff;G. McComsey;A. Eckard