Integrated Nanofluidic BioMEMS for Biomedical Diagnostics and Analysis

描述(由申请人提供)： 指导部分： 作为指导项目的一部分，候选人将把他发表的高通量多抗原荧光微流控免疫分析(BioTechniques 40：85-90)的成果推广到更复杂的样本，如人血清和血浆，从而为便携式微流控血液测试系统铺平道路。 相关性： 便携式微流控血液检测将在现代生物医学诊断中大大节省成本和时间，同时在总体上节省医疗保健。这样的系统还将使用指刺量的样本，消除了抽血的需要和血肿的危险，并使儿科患者，特别是婴儿更容易进行血液测试。低成本和少量样本也意味着更频繁和无处不在的检测，从而导致更早的诊断，从而挽救生命。 独立研究部分： 申请人的详细计划概述如下，包括用于病毒检测的微流控免疫分析，用于便携式诊断设备的纳米探测器和微流控集成，用于大规模细胞筛查的设备，用于现场法医分析的芯片上聚合酶链式反应机器，用于纳米医学芯片的嵌套生物阵列，未知样本的DNA嵌入器-分离器，以及微流控细胞转染器。

DESCRIPTION (provided by applicant): Mentored section: As part of the mentored project, the candidate would extend his published results of high-throughput multiantigen fluorescence microfluidic immunoassays (BioTechniques 40: 85-90) to more complex samples, such as human blood serum and plasma, thereby paving the way to portable microfluidic blood test systems. Relevance: Portable microfluidic blood tests would produce major savings in cost and time in modern biomedical diagnostics with concomitant savings in healthcare in general. Such systems would also use finger-prick amounts of sample, eliminating the need for phlebotomy and the danger of hematomas, as well as making blood tests more accessible to pediatric patients, particularly infants. Low costs and small amounts of sample would also mean more frequent and ubiquitous testing, resulting in earlier diagnosis and thus saving lives. Independent research section: The applicant has a detailed plan outlined further below and including microfluidic immunoassays for viral detection, nanodetector and microfluidics integration for portable diagnostic devices, devices for large-scale cellular screening, on-chip PCR machine for on-the-spot forensic analysis, nested bioarrays for nanomedicine chips, DNA intercalator-separator of unknown samples, and a microfluidic cellular transfector.