Integrated Nanofluidic BioMEMS for Biomedical Diagnostics and Analysis

描述（由申请人提供）： 辅导部分： 作为指导项目的一部分，候选人将把他发表的高通量多抗原荧光微流控免疫测定（BioTechniques 40：85-90）的结果扩展到更复杂的样品，如人血清和血浆，从而为便携式微流控血液检测系统铺平道路。 相关性： 便携式微流控血液检测将在现代生物医学诊断中节省大量成本和时间，同时节省一般医疗保健费用。这样的系统还将使用手指针刺量的样本，消除了静脉切开术的需要和血肿的危险，并使血液测试更容易为儿科患者，特别是婴儿。低成本和少量样本也意味着更频繁和更普遍的检测，从而导致早期诊断，从而挽救生命。 独立研究部门： 申请人具有下文进一步概述的详细计划，包括用于病毒检测的微流体免疫测定、用于便携式诊断装置的纳米检测器和微流体集成、用于大规模细胞筛选的装置、用于现场法医分析的芯片上PCR机器、用于纳米医学芯片的嵌套生物阵列、未知样品的DNA嵌入分离器和微流体细胞分离器。

DESCRIPTION (provided by applicant): Mentored section: As part of the mentored project, the candidate would extend his published results of high-throughput multiantigen fluorescence microfluidic immunoassays (BioTechniques 40: 85-90) to more complex samples, such as human blood serum and plasma, thereby paving the way to portable microfluidic blood test systems. Relevance: Portable microfluidic blood tests would produce major savings in cost and time in modern biomedical diagnostics with concomitant savings in healthcare in general. Such systems would also use finger-prick amounts of sample, eliminating the need for phlebotomy and the danger of hematomas, as well as making blood tests more accessible to pediatric patients, particularly infants. Low costs and small amounts of sample would also mean more frequent and ubiquitous testing, resulting in earlier diagnosis and thus saving lives. Independent research section: The applicant has a detailed plan outlined further below and including microfluidic immunoassays for viral detection, nanodetector and microfluidics integration for portable diagnostic devices, devices for large-scale cellular screening, on-chip PCR machine for on-the-spot forensic analysis, nested bioarrays for nanomedicine chips, DNA intercalator-separator of unknown samples, and a microfluidic cellular transfector.