Integrated Nanofluidic BioMEMS for Biomedical Diagnostics and Analysis

用于生物医学诊断和分析的集成纳米流体 BioMEMS

• 批准号: 7677888
• 负责人: Emil P Kartalov
• 金额: $ 24.87万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7677888
• 关键词: Blood Proteins; Blood Tests; Calibration; Childhood; Complex; DNA Microarray Chip; Data; Development; Devices; Diagnostic; Early Diagnosis; Ferritin; Fingers; Fluorescence; Forensic Medicine; Gold; Healthcare; Hematoma; Human; Immunoassay; Infant; Intercalating Agents; Life; Malignant Neoplasms; Measurement; Measures; Mentors; Microfluidics; Modems; Patients; Plasma; Publishing; Research; Sampling; Savings; Screening procedure; Sensitivity and Specificity; Serum; Solutions; Spottings; System; Techniques; Test Result; Time; Vascular Endothelial Growth Factors; Venous blood sampling; cost; nanofluidic; nanomedicine; novel; point-of-care diagnostics; viral detection

Mentored section: As part of the mentored project, the candidate would extend his published results of high-throughput multiantigen fluorescence microfluidic immunoassays (BioTechniques 40: 85-90) to more complex samples, such as human blood serum and plasma, thereby paving the way to portable microfluidic blood test systems. Relevance: Portable microfluidic blood tests would produce major savings in cost and time in modern biomedical diagnostics with concomitant savings in healthcare in general. Such systems would also use finger-prick amounts of sample, eliminating the need for phlebotomy and the danger of hematomas, as well as making blood tests more accessible to pediatric patients, particularly infants. Low costs and small amounts of sample would also mean more frequent and ubiquitous testing, resulting in earlier diagnosis and thus saving lives. Independent research section: The applicant has a detailed plan outlined further below and including microfluidic immunoassays for viral detection, nanodetector and microfluidics integration for portable diagnostic devices, devices for large-scale cellular screening, on-chip PCR machine for on-the-spot forensic analysis, nested bioarrays for nanomedicine chips, DNA intercalator-separator of unknown samples, and a microfluidic cellular transfector.

指导部分： 作为指导项目的一部分，候选人将扩展他发表的高通量多抗原研究成果。 荧光微流控免疫分析(BioTechniques 40：85-90)用于更复杂的样品，如 作为人体血清和血浆，从而为便携式微流控血液测试系统铺平了道路。 相关性： 便携式微流控血液检测将大大节省现代生物医学的成本和时间 诊断和相应的医疗保健方面的节省。这样的系统也会使用手指刺法 大量的样本，消除了静脉采血和血肿的危险，以及制作 儿童患者，特别是婴儿，更容易进行血液测试。低成本和少量的 样本也将意味着更频繁和无处不在的检测，从而更早地诊断，从而节省 活着。 独立研究部分： 申请人有一个详细的计划，下面进一步概述，并包括微流控免疫分析病毒 便携式诊断设备、大规模设备的检测、纳米探测器和微流控一体化 细胞筛查，用于现场法医分析的芯片PCR机，嵌套生物阵列 纳米药物芯片，未知样本的DNA嵌入器-分离器，以及微流控细胞转染器。